PMID: 8454903Apr 1, 1993Paper

Rate of stratum corneum formation in the perinatal rat

The Journal of Investigative Dermatology
Steven B HoathS T Boyce

Abstract

During late gestation, the fetal rat exhibits marked hyperplasia of the interfollicular epidermis and accelerated cornification in preparation for birth. In this study, we utilized simple morphometric techniques to provide quantitative estimates of the rate of stratum corneum (SC) formation during the perinatal period. Cryostat sections of dorsal epidermis from rat pups between -48 and +72 h of age were expanded under alkaline conditions and the number of corneocyte interfaces counted from photomicrographs. This method yielded the following regression lines: prenatal, y = 0.19x + 13.07, r = 0.93; postnatal, y = 0.13x + 13.00, r = 0.93, where y = number of SC layers and x = age in hours. Lack of desquamation was assured by the postnatal persistence of the granular periderm. Adhesive stripping of the epidermis followed by phase-contrast microscopy revealed intact monolayer sheets of SC. Quantitation using a computerized image analysis system gave an average corneocyte surface area in the newborn rat of 1908 +/- 36 mu 2 (mean +/- SEM). Treatment of neonatal rats with epidermal growth factor (500 ng/g BW) increased the number of SC layers over the first 24 h of life (p < 0.05) and resulted in marked hyperkeratosis by one week of ag...Continue Reading

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Citations

Sep 23, 2014·The British Journal of Dermatology·S B Hoath
Mar 18, 2000·Pediatric Dermatology·M O VisscherS B Hoath
Dec 14, 1999·The Journal of Investigative Dermatology·M J HardmanC Byrne
Jun 12, 2004·The Journal of Investigative Dermatology·Joachim W FluhrKenneth R Feingold
Dec 16, 2005·The Journal of Investigative Dermatology·Joachim W FluhrKenneth R Feingold

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