PMID: 11912569Mar 26, 2002Paper

Rate of switch in bipolar patients prospectively treated with second-generation antidepressants as augmentation to mood stabilizers

Bipolar Disorders
Robert M PostWillem A Nolen

Abstract

Bipolar patients with breakthrough major depressive episodes despite ongoing adequately-dosed mood stabilizer medication were randomized in a double-blind manner to one of three antidepressants with different mechanisms of action: bupropion, sertraline, or venlafaxine. Preliminary data are presented on the switch rates into hypomania or mania for the antidepressants as a group prior to unblinding the specific individual drug efficacy and tolerability data in this ongoing clinical trial. Subjects included 64 bipolar patients who participated at five sites in a 10-week double-blind trial for depression and a 1-year blinded continuation maintenance phase for responders. Nonresponders were re-randomized such that there were 95 acute treatment phases. In the acute phase, doses were titrated to clinical response, side effects, or maximum dose of bupropion (450 mg/day), sertraline (200 mg/day), or venlafaxine (375 mg/day). Daily ratings on the National Institute of Mental Health-Life Chart Methodology (NIMH-LCM) were inspected for the degree of improvement on the Clinical Global Impressions scale as revised for bipolar illness (CGI-BP) and the occurrence of hypomania or mania. Thirty-five (37%) of the 95 acute treatment phases were as...Continue Reading

Citations

Dec 14, 2002·Bipolar Disorders·Trisha SuppesRobert M Post
Oct 11, 2007·Annals of General Psychiatry·Konstantinos N FountoulakisGeorge S Kaprinis
Jul 29, 2009·Annals of General Psychiatry·Konstantinos N Fountoulakis, Eduard Vieta
Feb 20, 2010·Journal of Child and Adolescent Psychopharmacology·Kiki D ChangDiana Simeonova
Mar 26, 2011·Annals of General Psychiatry·Konstantinos N FountoulakisZoltan Rihmer
Aug 19, 2011·Current Psychiatry Reports·Oliver D Howes, Irina Falkenberg
Apr 23, 2003·Biological Psychiatry·Paul E KeckSusan L McElroy
Nov 27, 2007·Journal of Affective Disorders·Konstantinos N FountoulakisGeorge Kaprinis
Apr 27, 2007·Progress in Neuro-psychopharmacology & Biological Psychiatry·Gérard EmilienMichel Bourin
Mar 5, 2004·International Journal of Clinical Practice·Mark Zetin
Nov 11, 2011·CNS Neuroscience & Therapeutics·Konstantinos N Fountoulakis
Aug 30, 2008·Acta Psychiatrica Scandinavica·S N GhaemiR J Baldessarini
Dec 2, 2004·Journal of Affective Disorders·Janet WozniakKathryn Lail
May 24, 2011·Journal of Affective Disorders·Konstantinos N FountoulakisHagop Akiskal
Dec 24, 2014·Journal of Affective Disorders·R M Hirschfeld
Jun 15, 2005·Bipolar Disorders·Lakshmi N YathamUNKNOWN Canadian Network for Mood and Anxiety Treatments

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Bipolar Disorder

Bipolar disorder is characterized by manic and/or depressive episodes and associated with uncommon shifts in mood, activity levels, and energy. Discover the latest research this illness here.