Rate of telomere shortening and metabolic and cardiovascular risk factors: a longitudinal study in the 1934-44 Helsinki Birth Cohort Study

Annals of Medicine
Maria Angela GuzzardiJohan G Eriksson

Abstract

Leucocyte telomere length (LTL) is associated with age-related health outcomes, but only few longitudinal studies have assessed changes in LTL in an ageing population. A total of 1,082 subjects from the Helsinki Birth Cohort Study (born 1934-1944), undergoing two clinical visits ∼10 years apart, were studied. Relative LTL was measured twice by quantitative real-time PCR. Simple and multiple regressions were used to study associations between cardiometabolic risk factors and LTL. Telomere shortening was observed in 93.7%, and telomere elongation in 6.3% of the study participants. Telomere shortening was more rapid among males (-39.5% ± 1.1% versus -35.5% ± 1.0%, P < 0.01). In men a decrease in weight, waist circumference, BMI, and body fat percentage were all associated with telomere shortening during the follow-up (P < 0.05) independently of age and use of medication. Furthermore, higher body fat percentage and higher HDL-cholesterol level were associated with a slower rate of shortening in LTL (P < 0.05). Lower blood pressure levels were also associated with slower rate of telomere shortening in men (P < 0.05). No similar associations were observed among women. A decrease in adiposity was associated with telomere shortening, a...Continue Reading

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Citations

Feb 22, 2016·Psychoneuroendocrinology·Dóra RévészBrenda W J H Penninx
Apr 23, 2016·International Journal of Obesity : Journal of the International Association for the Study of Obesity·M A GuzzardiJ G Eriksson
Nov 2, 2016·Proceedings of the National Academy of Sciences of the United States of America·Alex Chia Yu ChangHelen M Blau
Dec 21, 2016·Journal of Applied Toxicology : JAT·F FinotR M'Kacher
Jun 7, 2017·Angiology·Mohsen MazidiMaciej Banach
Dec 22, 2016·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Nancy Monroy-JaramilloConsuelo Walss-Bass
Aug 22, 2017·American Journal of Physiology. Heart and Circulatory Physiology·Katarzyna PolonisPrachi Singh
Jan 16, 2019·European Journal of Clinical Nutrition·Jelena MeiniläJohan G Eriksson
Sep 7, 2019·Mechanisms of Ageing and Development·Max J ÅströmJohan G Eriksson
Jul 31, 2018·Journal of the American Medical Directors Association·Markus J HaapanenMikaela B von Bonsdorff
Feb 24, 2020·Gerontology·Hanna JantunenJohan G Eriksson

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