Rate pressure product and the components of heart rate and systolic blood pressure in hospitalized heart failure patients with preserved ejection fraction: Insights from ASCEND-HF

Clinical Cardiology
Amanda K VermaRobert J Mentz

Abstract

Heart rate and systolic blood pressure (SBP) are prognostic markers in heart failure (HF) with reduced ejection fraction (HFrEF). Their combination in rate pressure product (RPP) as well as their role in heart failure with preserved ejection fraction (HFpEF) remains unclear. RPP and its components are associated with HFpEF outcomes. We performed an analysis of Acute Study of Clinical Effectiveness of Nesiritide in Subjects With Decompensated Heart Failure (ASCEND-HF; http://www.clinicaltrials.gov NCT00475852), which studied 7141 patients with acute HF. HFpEF was defined as left ventricular ejection fraction ≥40%. Outcomes were assessed by baseline heart rate, SBP, and RPP, as well as the change of these variables using adjusted Cox models. After multivariable adjustment, in-hospital change but not baseline heart rate, SBP, and RPP were associated with 30-day mortality/HF hospitalization (hazard ratio [HR]: 1.17 per 5-bpm heart rate, HR: 1.20 per 10-mm Hg SBP, and HR: 1.02 per 100 bpm × mm Hg RPP; all P < 0.05). Baseline SBP was associated with 180-day mortality (HR: 0.88 per 10-mm Hg, P = 0.028). Though change in RPP was associated with 30-day mortality/HF hospitalization, the RPP baseline variable did not provide additional as...Continue Reading

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Citations

Jun 10, 2020·Journal of Hypertension·Erik J M van BommelDaniël H van Raalte
Oct 10, 2020·The Journal of Clinical Hypertension·Babak YazdaniBernhard K Krämer
Oct 4, 2020·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Jonathon A HagelJohn N Kheir
Jan 30, 2021·Journal of Perinatology : Official Journal of the California Perinatal Association·R E GiesingerP J McNamara
Feb 20, 2021·Journal of Perinatology : Official Journal of the California Perinatal Association·Rohit S LoombaRonald Bronicki
Apr 15, 2021·Journal of Medical Engineering & Technology·Ofer HavakukYaron Arbel

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