Rates and determinants of site-specific progression of carotid artery intima-media thickness: the carotid atherosclerosis progression study

Stroke; a Journal of Cerebral Circulation
Andrew D MackinnonHugh S Markus

Abstract

Carotid intima-media thickness (IMT) progression rates are increasingly used as an intermediate outcome for vascular risk. The carotid bifurcation (BIF) and internal carotid artery (ICA) are predilection sites for atherosclerosis. IMT measures from these sites may be a better estimate of atherosclerosis than common carotid artery (CCA) IMT. The study aim was to evaluate site-specific IMT progression rates and their relationships to vascular risk factors compared with baseline IMT measurements. In a community population (n=3383), ICA-IMT, BIF-IMT, CCA-IMT, and vascular risk factors were evaluated at baseline and at 3-year follow-up. Mean (SD) IMT progression was significantly greater at the ICA (0.032 [0.109] mm/year) compared with the BIF (0.023 [0.108] mm/year) and the CCA (0.001 [0.040] mm/year) (P<0.001). Only ICA-IMT progression significantly correlated with baseline vascular risk factors (age, male gender, hypertension, diabetes, and smoking). Change in risk factor profile over follow-up, estimated using the Framingham risk score, was a predictor of IMT progression only. For all arterial sites, correlations were stronger, by a factor of 2 to 3, for associations with baseline IMT compared with IMT progression. Progression r...Continue Reading

References

Feb 21, 1998·Annals of Internal Medicine·H N HodisS P Azen
Jul 28, 2001·The American Journal of Cardiology·J R Crouse
Dec 26, 2001·Annals of Epidemiology·N David YanezUNKNOWN Cardiovascular Health Study
May 15, 2002·Journal of Cardiovascular Risk·Matthias SitzerHelmuth Steinmetz
Apr 19, 2003·Arteriosclerosis, Thrombosis, and Vascular Biology·Lynne E WagenknechtSteven M Haffner

❮ Previous
Next ❯

Citations

Jun 22, 2006·Cerebrovascular Diseases·Wakoh TakahashiYukito Shinohara
Nov 29, 2007·Cerebrovascular Diseases·Jaime GállegoRoberto Muñoz
Mar 7, 2009·Stroke; a Journal of Cerebral Circulation·José R RomeroPhilip A Wolf
Jan 23, 2008·Cardiovascular Ultrasound·Kathleen PotterLeonard F Arnolda
Mar 31, 2011·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Latika SibalPhilip D Home
May 14, 2009·Vascular Health and Risk Management·J P BaguetJ M Mallion
Aug 17, 2011·Journal of Atherosclerosis and Thrombosis·Soner DoganMichiel Leonardus Bots
Mar 1, 2012·Journal of Occupational and Environmental Medicine·Jefferey L BurgessMatthew Allison
Jan 12, 2005·Journal of Hypertension·Luc M Van Bortel
Apr 13, 2012·Journal of Hypertension·Claudia R L CardosoGil F Salles
Oct 16, 2007·Annals of Medicine·Damiano BaldassarreCesare R Sirtori
Dec 4, 2010·Journal of the American College of Cardiology·Pierluigi CostanzoMassimo Chiariello
Nov 17, 2009·The New England Journal of Medicine·Roger S Blumenthal, Erin D Michos
Jan 16, 2013·Neurologia i neurochirurgia polska·Wojciech Bartman, Krystyna Pierzchała
Sep 25, 2012·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Sanne A E PetersUNKNOWN METEOR Study Group
Sep 1, 2015·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Maged AbdelnaseerEnji Elsawy
Oct 11, 2011·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Sanne A E PetersUNKNOWN METEOR Study Investigators
Sep 13, 2011·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·M KozàkovàP M Nilsson
Mar 29, 2011·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Eric Y YangVijay Nambi
Jun 18, 2010·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·R Molino-LovaL Ferrucci
Nov 6, 2008·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Jose R RomeroSudha Seshadri
Sep 22, 2015·International Journal of Obesity : Journal of the International Association for the Study of Obesity·R LupoliG Mingrone
Dec 3, 2005·International Journal of Geriatric Psychiatry·Cheng-Sheng ChenHsiu-Fen Lin
Mar 23, 2012·Acta Neurologica Scandinavica·G TelmanE Kouperberg
Oct 4, 2011·Arthritis and Rheumatism·Jon T GilesJoan M Bathon
Oct 24, 2014·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Marina DiomediMauro Silvestrini
Sep 5, 2006·Journal of Diabetes and Its Complications·Larry A DistillerGreg B Distiller
Dec 15, 2010·The American Journal of Cardiology·Quoc Manh NguyenGerald S Berenson
Apr 6, 2016·Acta Neurologica Scandinavica·M O OwolabiA M Agunloye
Dec 11, 2013·Journal of Stroke·Sanne A E Peters, Michiel L Bots

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atherosclerosis Disease Progression

Atherosclerosis is the buildup of plaque on artery walls, causing stenosis which can eventually lead to clinically apparent cardiovascular disease. Find the latest research on atherosclerosis disease progression here.

Carotid Artery Diseases

Carotid artery disease is a group of pathological conditions of the carotid artery. Discover the latest research on carotid artery disease here.