Rates and Predictors of HIV-Exposed Infants Lost to Follow-Up During Early Infant Diagnosis Services in Kenya

AIDS Patient Care and STDs
Kathy GogginSarah Finocchario-Kessler

Abstract

Early infant diagnosis (EID) involves age-specific tracking and testing of HIV-exposed infants during the first 18 months of life and rapid initiation of life-saving treatment for those infected. In Kenya, pre-2013 data estimate EID lost to follow-up (LTFU) at 39-65%, yet no study has documented LTFU rates and predictors throughout the EID cascade since Option B+ fundamentally changed services by placing all HIV-positive expectant mothers on lifelong treatment. Using an explanatory mixed-method design, we assessed LTFU rates and predictors among 870 mother-infant dyads enrolled in EID in six urban/peri-urban Kenyan government hospitals. Mothers completed baseline surveys, and dyads were tracked through EID. We selected 12 baseline variables and modeled odds of LTFU at 9 and 18 months using mixed logistic regression. Qualitative interviews were conducted with 61 mothers to assess barriers and facilitators to completing EID. Thematically coded transcripts were used to interpret quantitative predictors of LTFU. By the 18-month test, 145 dyads (22%) were LTFU, with three-quarters of LTFU occurring between 9- and 18-month tests. Odds of LTFU at 18 months decreased by 10% for each additional year of maternal age and by 66% with HIV s...Continue Reading

Associated Clinical Trials

References

Nov 21, 2008·The New England Journal of Medicine·Avy ViolariUNKNOWN CHER Study Team
Jan 8, 2011·AIDS and Behavior·Amin S HassanJames A Berkley
Jan 27, 2011·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Rebecca E CookTroy D Moon
Mar 17, 2011·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Paula BraitsteinConstantin Yiannoutsos
Aug 5, 2014·Tropical Medicine & International Health : TM & IH·Hannock TweyaSam Phiri
Dec 4, 2014·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Selamawit A WoldesenbetGayle G Sherman
Jun 18, 2015·AIDS and Behavior·Lori A J Scott-SheldonUNKNOWN MASH Research Team
Jul 15, 2015·Implementation Science : IS·Sarah Finocchario-KesslerVincent Okoth
Apr 25, 2016·AIDS and Behavior·Kathy GogginSarah Finocchario-Kessler
Apr 12, 2017·Journal of Acquired Immune Deficiency Syndromes : JAIDS·David HarozKarusa Kiragu

❮ Previous
Next ❯

Citations

Jun 11, 2020·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Lynne M MofensonEmma Sacks
Apr 15, 2020·Maternal and Child Health Journal·Catherine WexlerSarah Finocchario-Kessler
Oct 29, 2020·Infectious Diseases and Therapy·Chalachew Adugna WubnehAklilu Endalamaw

❮ Previous
Next ❯

Methods Mentioned

BETA
PCR

Clinical Trials Mentioned

NCT02072603

Software Mentioned

Excel
R
mice
SAS MIANALYZE
SAS
Atlas
Ubuntu LAMP
Linux
ti

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.