Rates and predictors of progression to esophageal carcinoma in a large population-based Barrett's esophagus cohort

Gastrointestinal Endoscopy
Rajesh KrishnamoorthiPrasad G Iyer

Abstract

Rates of progression to esophageal adenocarcinoma in subjects with Barrett's esophagus (BE) are lower than previously estimated. Identification of predictors of progression will enable risk stratification of BE subjects, potentially making current surveillance programs more efficient. We aimed to assess the potential of demographic and lifestyle factors, obesity, and medications in predicting progression in BE. BE subjects were identified from the General Practice Research Database using validated diagnostic codes. BE subjects developing esophageal cancer (EC) 12 months after their index BE diagnosis were defined as progressors. Time-to-event analysis was used to assess the overall risk of progression to EC. Cox proportional hazards models and time-varying marginal structural models were used to assess predictors of progression. Included in the analysis were 9660 BE patients. The mean age (SD) of the study subjects was 63 (13.5) years; 62.6% were men. One hundred three subjects (1.1%) progressed to EC. The mean (SD) follow-up since initial diagnosis was 4.8 (3.3) years. The incidence of EC was 2.23 per 1000 person-years of follow-up. Increasing age, male gender, and being overweight (body mass index, 25-29.9) were found to be i...Continue Reading

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Citations

Feb 28, 2017·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Rajesh KrishnamoorthiPrasad G Iyer
Feb 6, 2017·European Journal of Gastroenterology & Hepatology·Christine Royston, Karna D Bardhan
Jan 17, 2017·Gastrointestinal Endoscopy·Rajesh KrishnamoorthiPrasad G Iyer
Mar 23, 2017·The Surgical Clinics of North America·Guillermo Gomez
Jun 30, 2019·BMC Gastroenterology·Thomas L VaughanJames Y Dai
May 2, 2018·Digestive Diseases and Sciences·Fouad Otaki, Prasad G Iyer
Feb 24, 2019·Current Treatment Options in Gastroenterology·Subhankar Chakraborty, Prasad G Iyer
Nov 2, 2020·Cellular and Molecular Gastroenterology and Hepatology·May San MartinhoDipankar Ray
Mar 30, 2021·Frontiers in Oncology·Jessie A Elliott, John V Reynolds
Nov 21, 2020·Gastrointestinal Endoscopy Clinics of North America·Michael B Cook, Aaron P Thrift
Jun 1, 2021·Journal of Gastrointestinal Cancer·Ali Fatehi Hassanabad, Jonathan V S Wong
May 29, 2021·The Surgical Clinics of North America·Thomas Fabian, Alexander Leung
Oct 14, 2021·Journal of Neurogastroenterology and Motility·Hye-Kyung JungUNKNOWN Korean Society of Neurogastroenterology and Motility

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