Rates and predictors of seizure outcome after corpus callosotomy for drug-resistant epilepsy: a meta-analysis

Journal of Neurosurgery
Alvin Y ChanDario J Englot

Abstract

OBJECTIVECorpus callosotomy is a palliative surgery for drug-resistant epilepsy that reduces the severity and frequency of generalized seizures by disconnecting the two cerebral hemispheres. Unlike with resection, seizure outcomes remain poorly understood. The authors systematically reviewed the literature and performed a meta-analysis to investigate rates and predictors of complete seizure freedom and freedom from drop attacks after corpus callosotomy.METHODSPubMed, Web of Science, and Scopus were queried for primary studies examining seizure outcomes after corpus callosotomy published over 30 years. Rates of complete seizure freedom or drop attack freedom were recorded. Variables showing a potential relationship to seizure outcome on preliminary analysis were subjected to formal meta-analysis.RESULTSThe authors identified 1742 eligible patients from 58 included studies. Overall, the rates of complete seizure freedom and drop attack freedom after corpus callosotomy were 18.8% and 55.3%, respectively. Complete seizure freedom was significantly predicted by the presence of infantile spasms (OR 3.86, 95% CI 1.13-13.23), normal MRI findings (OR 4.63, 95% CI 1.75-12.25), and shorter epilepsy duration (OR 2.57, 95% CI 1.23-5.38). Fr...Continue Reading

References

Apr 1, 1991·Journal of Neurosurgery·K S FuiksG Somes
Apr 1, 1991·Archives of Neurology·R E NordgrenD W Roberts
Jan 1, 1989·Bollettino della Società italiana di biologia sperimentale·B CensoriI Papo
Jan 1, 1987·Epilepsia·J R GatesR E Lyons
Jan 1, 1988·Neurology·S S SpencerR H Mattson
Jan 1, 1988·Epilepsy Research·A M MurroJ R Smith
Jan 1, 1987·Applied Neurophysiology·E Garcia-Flores
Aug 1, 1996·British Journal of Neurosurgery·J Phillips, D E Sakas
Jun 10, 1998·Pediatric Neurosurgery·J M SorensonL J Willmore
Jul 13, 1999·Annals of Neurology·M R SperlingM J O'Connor
Dec 28, 1999·Epilepsia·J M PinardO Dulac
Feb 5, 2000·The New England Journal of Medicine·P Kwan, M J Brodie
Feb 9, 2000·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·S Y KwanM S Su
May 1, 2004·Yonsei Medical Journal·Dong-Seok KimByung-In Lee
Nov 3, 2004·Epilepsy Research·C ToniniS Wiebe
Mar 11, 2005·Brain : a Journal of Neurology·José F Téllez-ZentenoSamuel Wiebe
Sep 3, 2005·Seizure : the Journal of the British Epilepsy Association·Shang-Yeong KwanChun-Hing Yiu
Mar 23, 2006·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Güzide TuranliMeral Topçu
Apr 4, 2006·Lancet·John S DuncanMatthew C Walker
Oct 28, 2006·Seizure : the Journal of the British Epilepsy Association·Sigmund JenssenMichael O'Connor
Apr 6, 2007·Pediatric Neurosurgery·Scott Y RahimiMark R Lee
May 18, 2007·Brain & Development·Chaturbhuj RathoreKurupath Radhakrishnan
Jun 10, 2008·Epilepsy & Behavior : E&B·Ali A Asadi-PooyaMichael R Sperling
Jul 2, 2008·Journal of Neurosurgery. Pediatrics·Kyu-Won ShimDong-Seok Kim
Sep 19, 2008·Seizure : the Journal of the British Epilepsy Association·Shigeki SunagaHidenori Sugano
Feb 28, 2009·Journal of Neurosurgery·Taner TanriverdiFrançois Dubeau
May 5, 2009·Seizure : the Journal of the British Epilepsy Association·Zheng PingTian Xin
Jul 22, 2009·PLoS Medicine·David MoherUNKNOWN PRISMA Group
Jun 10, 2010·Stereotactic and Functional Neurosurgery·Shuli LiangYajing Sun
Sep 3, 2010·Journal of Neurosurgery. Pediatrics·Laleh JalilianMatthew D Smyth

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Citations

Oct 5, 2019·Expert Review of Neurotherapeutics·Jasmina R MilovanovićSrđan Stefanović
Apr 14, 2020·International Journal of General Medicine·Muhamad Thohar ArifinJacob Bunyamin
Jul 31, 2021·Pediatric Neurology·Fernando N GalanRaj D Sheth

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