Rates, factors, reasons, and economic impact associated with switching in rheumatoid arthritis patients newly initiated on biologic disease modifying anti-rheumatic drugs in an integrated healthcare system

Journal of Medical Economics
Nazia RashidChad Patel

Abstract

Objectives To identify how many RA patients newly-initiated on bDMARD therapy switch to another bDMARD during the first year of treatment; to evaluate the factors and reasons associated with bDMARD switching; and to compare the RA-related healthcare resource utilization (HCRU) and costs between switchers vs non-switchers during the post-index period. Methods A retrospective cohort study was conducted in RA patients using the Kaiser Permanente Southern California (KPSC) database with the study time period of January 1, 2007 to December 31, 2012. The index date was defined as the date of the first bDMARD prescription. Patients had to have continuous membership eligibility with drug benefit and no prior history of bDMARD during the 24 months prior to the index date. bDMARD switching was defined as a different bDMARD claim during post-index. A multivariable logistic regression model was used to evaluate factors associated with switchers vs non-switchers. Chart notes were reviewed to evaluate reasons for switching from index bDMARD. RA-related HCRU use and costs were evaluated using a generalized linear model (GLM) with gamma distribution and log link function. Results Two hundred and fifty-one patients (12%) switched from their ind...Continue Reading

References

Mar 1, 2005·Lupus·M Aringer, J S Smolen
Dec 13, 2005·Annals of the Rheumatic Diseases·A FinckhUNKNOWN SCQM physicians
Mar 2, 2006·Arthritis Research & Therapy·Juan J Gomez-ReinoUNKNOWN BIOBADASER Group
Apr 13, 2006·Clinical Rheumatology·Peter M Brooks
May 17, 2007·Rheumatology·S BombardieriUNKNOWN Research in Active Rheumatoid Arthritis (ReAct) Study Group
Jun 20, 2007·Annals of the Rheumatic Diseases·Ronald F van Vollenhoven
Jan 26, 2011·Autoimmunity Reviews·Fabiola AtzeniRoberto Caporali
Mar 22, 2014·MedChemComm·Martin GolkowskiShao-En Ong

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Citations

Sep 16, 2019·The European Journal of Health Economics : HEPAC : Health Economics in Prevention and Care·Axel SvedbomSumesh Kachroo

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