Rates of allergic sensitization and irritation to oxybenzone-containing sunscreen products: a quantitative meta-analysis of 64 exaggerated use studies

Photodermatology, Photoimmunology & Photomedicine
Patricia P AginTimothy J McCarthy

Abstract

Oxybenzone is an active ingredient found in sunscreen products that absorbs a broad spectrum of ultraviolet (UV) light, with absorbance peaking in the UVB region and extending into the UVA region. Although the overall incidence of sensitization and irritation associated with oxybenzone in the general population remains unclear, a few studies have reported on the incidence in specific circumstances. However, the relevance of these studies to the general population is limited, because the sample populations reported in these papers generally have consisted of individuals who sought medical attention for pre-existing skin conditions. Therefore, the reported incidence of allergic reactions to oxybenzone in these studies may be overestimated as related to the general population. The objective of this meta-analysis was to determine the safety of oxybenzone in participants recruited from the general population. The data from 64 unpublished exaggerated use human repeat insult patch tests (HRIPT) and photoallergy (PA) studies sponsored by Schering-Plough HealthCare Products Inc. between 1992 and 2006 were aggregated and analyzed to evaluate the irritancy and sensitization potential of sunscreen products containing oxybenzone at concentr...Continue Reading

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Apr 27, 2010·Photodermatology, Photoimmunology & Photomedicine·Alastair Kerr, James Ferguson
Dec 11, 2013·Journal of the European Academy of Dermatology and Venereology : JEADV·R WanitphakdeedechaW Manuskiatti
Mar 17, 2015·Photodermatology, Photoimmunology & Photomedicine·Rachel NovickKen Unice
Jun 21, 2019·Journal of Cutaneous Medicine and Surgery·Heidi LiJennifer Beecker

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