Abstract
Data on asthma treatment outcomes in Africa are limited. 449 patients with asthma (age 5-93 years) in Uganda were followed up for 2 years to determine rates of exacerbations and mortality and associated factors. During follow-up the median number of exacerbations per patient was 1 (IQR 0-5) and 17 patients died (3.7%, 27.3 deaths per 1000 person years). Considering only the first year of follow-up, 59.6% of the patients experienced at least one exacerbation, 32.4% experienced three or more exacerbations. A multivariable model showed that the likelihood of experiencing at least one exacerbation in the first year of follow-up was lower with better baseline asthma control (higher asthma control test (ACT) score), with OR 0.87 (95% CI: 0.82 to 0.93, P=0.000), and was higher with more exacerbations in the year prior to enrolment (OR for log number of exacerbations 1.28, 95% CI: 1.04 to 1.57, P=0.018). Better asthma control (OR 0.93, 95% CI: 0.88 to 0.99, P=0.021) and number of baseline exacerbations (OR 1.35,95% CI: 1.11 to 1.66, P=0.005) were also the only factors that were independently associated with experiencing three or more exacerbations during the first year of follow-up. The only factor found to be associated with all-cause...Continue Reading
References
Aug 16, 2005·Respiratory Medicine·Stephen LaneTadeusz Plusa
Aug 18, 2005·Respiratory Research·Roberto de MarcoAlessandra Marinoni
Jan 2, 2008·The European Respiratory Journal·E D BatemanH J Zar
Feb 4, 2009·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·R H Dougherty, J V Fahy
Apr 16, 2011·Journal of the American Society of Hypertension : JASH·Gerald S BerensonSathanur R Srinivasan
Sep 29, 2011·Archives of Internal Medicine·Lydie A Lebrun, Thomas A LaVeist
Mar 9, 2013·Chest·Zarqa AliCharlotte Suppli Ulrik
Sep 13, 2014·The Journal of Allergy and Clinical Immunology. in Practice·Michael SchatzMario Castro
Dec 23, 2014·Lancet·UNKNOWN GBD 2013 Mortality and Causes of Death Collaborators
Oct 22, 2016·The Lancet Global Health·Peter Byass
Nov 28, 2016·Respiratory Medicine·Talitha ComaruLeonardo A Pinto
Feb 6, 2017·Respirology : Official Journal of the Asian Pacific Society of Respirology·Claus F VogelmeierAlvar Agusti
Aug 12, 2017·Lancet·Stefan EbmeierRichard Beasley
Feb 2, 2018·The European Respiratory Journal
Citations
May 20, 2018·Thorax·J Mark FitzGerald, Khalid Al Efraij
Jul 14, 2020·Wellcome Open Research·Harriet MpairweAlison M Elliott
May 13, 2020·BMC Health Services Research·Rebecca NantandaBruce J Kirenga
Jun 22, 2019·Respirology : Official Journal of the Asian Pacific Society of Respirology·Vanessa M McDonald, Peter G Gibson
Jun 20, 2020·NPJ Primary Care Respiratory Medicine·Monica J FletcherThys van der Molen
Jan 23, 2021·Thorax·Sarah RylanceKevin Mortimer
Jun 17, 2021·Cadernos de saúde pública·Cyndielle Barcelos da RochaClóvis Botelho
Oct 30, 2021·The Journal of Allergy and Clinical Immunology·Chrysanthi SkevakiHarald Renz