Rates of circumferential resection margin involvement vary between surgeons and predict outcomes in rectal cancer surgery

Annals of Surgery
Kevin F BirbeckPhilip Quirke

Abstract

To analyze the potential variability in rates of circumferential resection margin (CRM) involvement between different surgeons and time periods and to determine the suitability of using CRM status as an immediate predictor of outcome after rectal cancer surgery. After disease stage has been taken into account, survival in rectal cancer has been shown to be very variable between surgeons and institutions. One of the major factors influencing survival is local recurrence, and this in turn is strongly related to inadequate tumor excision, particularly at the CRM. In a study involving 608 patients who underwent surgery for rectal cancer in Leeds during the 12-year period 1986 to 1997, the authors examined the role of CRM status as an immediate predictor of likely outcome, paying particular attention to its relationships with different surgeons and time periods. Of 586 patients on whom full clinical follow-up was obtained, 165 (28.2%) had CRM involvement by carcinoma on pathologic examination. Up to the end of 1998, 105 (17.9%) patients had developed local recurrence. A significantly higher proportion (38.2%) of CRM-positive patients developed local recurrence than CRM-negative ones (10.0%). Kaplan-Meier survival analysis showed sig...Continue Reading

References

Jun 1, 1988·International Journal of Colorectal Disease·P Quirke, M F Dixon
Mar 1, 1996·The British Journal of Surgery·G ArbmanR Sjödahl
Jun 1, 1996·The British Journal of Surgery·D F de Haas-KockJ W Arends
Mar 6, 1998·Annals of Surgery·G A PorterS C Newman
Aug 26, 1998·Archives of Surgery·R J HealdJ K MacFarlane

❮ Previous
Next ❯

Citations

Mar 3, 2006·Der Chirurg; Zeitschrift für alle Gebiete der operativen Medizen·J R SiewertR Rosenberg
Nov 9, 2012·Cancer Chemotherapy and Pharmacology·Jingquan LiMudan Zhu
Apr 1, 2005·International Journal of Colorectal Disease·S O BreukinkW J H J Meijerink
Mar 30, 2007·International Journal of Colorectal Disease·Cameron F E Platell
Jul 11, 2007·International Journal of Colorectal Disease·Felix AignerHelga Fritsch
Jul 3, 2008·International Journal of Colorectal Disease·Shin FujitaYoshihiro Moriya
Jul 18, 2008·International Journal of Colorectal Disease·Joachim StrassburgPaul Hermanek
May 24, 2011·International Journal of Colorectal Disease·Sigmar StelznerHelmut Witzigmann
Nov 1, 2011·International Journal of Colorectal Disease·Ilmo KellokumpuKyösti Nuorva
Jul 29, 2005·Langenbeck's Archives of Surgery·Cun WangWeiping Liu
Mar 24, 2005·Diseases of the Colon and Rectum·Kirsten M BoyleIan Eardley
May 6, 2005·Diseases of the Colon and Rectum·Joe J TjandraUNKNOWN American Society of Colon and Rectal Surgeons
Jun 7, 2005·Diseases of the Colon and Rectum·Frédérique PeschaudBernard Nordlinger
Oct 10, 2006·Diseases of the Colon and Rectum·Kishore K SasapuPaul J Finan
Sep 17, 2009·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Rolv-Ole Lindsetmo, Conor P Delaney
Feb 10, 2010·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·In Ja Park, Jin Cheon Kim
Mar 17, 2010·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·Xavier SanjuánUNKNOWN Colorectal Cancer OncoGuia Group
May 15, 2010·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·Carmen FausSamuel Navarro
Sep 24, 2004·European Journal of Radiology·Joo Hee KimRegina G H Beets-Tan
Jul 8, 2009·The Surgeon : Journal of the Royal Colleges of Surgeons of Edinburgh and Ireland·M McCourtJ R T Monson
Sep 25, 2002·ANZ Journal of Surgery·Cameron PlatellPhillip Claringbold
Aug 1, 2007·Clinics in Colon and Rectal Surgery·Kirk A Ludwig
Apr 5, 2012·Annals of Oncology : Official Journal of the European Society for Medical Oncology·J V SchouB V Jensen
Jun 11, 2009·Journal of the National Cancer Institute·Karl Y BilimoriaUNKNOWN Pancreatic Cancer Quality Indicator Development Expert Panel, American College of Surgeons
Feb 25, 2005·Annals of Surgery·Eric RullierFrank Zerbib
Mar 26, 2008·Annals of Surgery·Caroline S Verbeke, Krishna V Menon
Dec 19, 2008·Annals of Surgery·Frédérique PeschaudBernard Nordlinger
Jun 30, 2009·Annals of Surgery·Christophe LaurentEric Rullier
Nov 26, 2010·Annals of Surgery·Daniel LeonardUNKNOWN PROCARE, a multidisciplinary Belgian Project on Cancer of the Rectum
Apr 28, 2004·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland
Sep 1, 2004·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·C C ThornN S Ambrose
Apr 30, 2005·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·K M BoyleD Burke
Mar 8, 2006·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·W HohenbergerJ Göhl
Feb 10, 2006·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·A Radcliffe
Jul 4, 2006·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·I R DanielsB J Moran
Dec 22, 2006·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·L H IversenUNKNOWN Danish Colorectal Cancer Group
Apr 17, 2007·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·I R DanielsB J Moran
Jan 17, 2007·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·O F DentE L Bokey
May 31, 2007·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·M Hosseinali KhaniW Kraaz
Sep 11, 2007·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·N Bagla, J B Schofield
Dec 12, 2007·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·J SuárezC Zazpe

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.