PMID: 233717Nov 1, 1975Paper

Rates of ion movement from plasma to endolymph in the dogfish

The Annals of Otology, Rhinology, and Laryngology
T H MarenA D Addink

Abstract

The rates of movement of Na+, Rb+, Cl- and HCO3- from plasma to endolymph were studied in the elasmobranch fish, Squalus acanthias, by use of the appropriate isotopes. Rb+ was used as a marker for K+. The half-times to equilibrium for Na+, Rb+ and Cl- were about 100 hours; for HCO3- it was 6 hours. The equilibrium ratios, endolymph/plasma, are Na+ 0.87, K+ 26, Cl- 1.37, HCO3- 1.47. Carbonic anhydrase inhibition decreased the rate of HCO3- accumulation, suggesting that the process is actually the formation of endolymphatic HCO3- from plasma or tissue CO2. Increase in plasma pCO2 elevates endolymph HCO3- concentration. The secretory tissue contains carbonic anhydrase and Na-K-ATPase. These and other data suggest that a dominant feature of endolymph chemistry may be HCO3- formation linked in some fashion with K+ transport, through rates catalyzed by these two enzymes.

References

Mar 1, 1975·The American Journal of Physiology·B P Vogh, T H Maren
Jul 1, 1973·The American Journal of Physiology·E J SimonM Kashgarian
Oct 1, 1967·Physiological Reviews·T H Maren
Mar 5, 1971·Science·E S CohnS W Brusilow
Jan 1, 1967·Canadian Journal of Physiology and Pharmacology·H M PappiusJ B Dossetor
Feb 11, 1961·Nature·S D ERULKAR, T H MAREN
Mar 1, 1965·The Annals of Otology, Rhinology, and Laryngology·Y B CHOO, D TABOWITZ

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