Rates of left ventricular isovolumic pressure rise and fall from the aortic regurgitation velocity signal: description of the method and validation in human beings

Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography
R G Pai, L N Stoletniy

Abstract

Aortic regurgitation results from a pressure gradient across the aortic valve during left ventricular (LV) isovolumic relaxation, LV filling, and isovolumic contraction periods. Assuming the applicability of the simplified Bernoulli equation to this pressure-flow relation and constancy of aortic pressure during LV isovolumic relaxation and contraction periods, one can theoretically obtain estimates of the rates of LV isovolumic pressure fall and rise (deltaP/delta t) from the aortic regurgitation (AR) velocity signal. Mitral regurgitation (MR) and AR signals were recorded by using the continuous wave Doppler technique in 26 patients with combined mitral and aortic regurgitant lesions. The LV negative deltaP/delta t was obtained by dividing the time taken for the AR velocity to rise from 1 m/sec to 2.5 m/sec into 21 mm Hg, which is the estimated LV pressure drop between these points. In a similar fashion, the LV positive deltaP/delta t was obtained between 2.5 m/sec and 1 m/sec of the fast decelerating portion of the AR signal. The LV negative deltaP/delta t by the AR method ranged from 420 to 3500 mm Hg/sec and correlated well with that obtained by the MR method obtained in a blinded fashion (r = 0.95, p < 0.0001). The mean (SD...Continue Reading

References

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Citations

Oct 29, 2000·Journal of Cardiothoracic and Vascular Anesthesia·G PoortmansJ Poelaert
Nov 23, 2006·Journal of the American College of Cardiology·Partho P SenguptaBijoy K Khandheria

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