Rates of Local Retinal Nerve Fiber Layer Thinning before and after Disc Hemorrhage in Glaucoma

Ophthalmology
Tadamichi AkagiRobert N Weinreb

Abstract

To investigate longitudinal temporal and spatial associations between disc hemorrhage (DH) and rates of local retinal nerve fiber layer (RNFL) thinning before and after DHs. Longitudinal, observational cohort study. Forty eyes of 37 participants (23 with glaucoma and 17 with suspect glaucoma at baseline) with DH episodes during follow-up from the Diagnostic Innovations in Glaucoma Study and the African Descent and Glaucoma Evaluation Study. All subjects underwent optic disc photography annually and spectral-domain optical coherence tomography (OCT) RNFL thickness measurements every 6 months. The rates of RNFL thinning were calculated using multivariate linear mixed-effects models before and after DH. Rates of global and local RNFL thinning. Thirty-six eyes of 33 participants with inferior or superior DHs were analyzed. The rates of RNFL thinning were significantly faster in DH quadrants than in non-DH quadrants after DH (-2.25 and -0.69 μm/year; P < 0.001). In the 18 eyes with intensified treatment after DH, the mean rate of RNFL thinning significantly slowed after treatment compared with before treatment in the non-DH quadrants (-2.89 and -0.31 μm/year; P < 0.001), but not in the DH quadrants (-2.64 and -2.12 μm/year; P = 0.19...Continue Reading

Associated Clinical Trials

Sep 22, 2005·Linda Zangwill

Citations

Aug 2, 2019·Investigative Ophthalmology & Visual Science·Eun Ji LeeHyunjoong Kim
Aug 10, 2019·The British Journal of Ophthalmology·Yong Woo KimKi Ho Park
Jun 14, 2020·Acta Ophthalmologica·Rei SakataUNKNOWN for Lower Normal Pressure Glaucoma Study Members in Japan Glaucoma Society
Jun 19, 2019·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Koji NittaYutaro Yamada
May 3, 2019·Investigative Ophthalmology & Visual Science·Ahnul HaJin Wook Jeoung
Jun 15, 2019·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Yun HsiaJehn-Yu Huang
Aug 25, 2020·Ophthalmology. Glaucoma·Tomomi HigashideUNKNOWN for SVF prospector study group
Jun 10, 2021·American Journal of Ophthalmology·Ryan Caezar C DavidRobert N Weinreb

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