PMID: 6536880Jan 1, 1984Paper

Rates of protein synthesis and degradation in Gunn rat cerebellum with bilirubin-induced cerebellar hypoplasia

Neurochemical Pathology
R Katoh-Semba, S Kashiwamata

Abstract

The rates of protein synthesis and degradation, and the endogenous leucine content on days 13 and 30, were examined in the cerebellum of homozygous Gunn rats with cerebellar hypoplasia and compared with those of heterozygotes. The rate of protein synthesis based on milligrams of protein was significantly lower on day 30 and the degradation rate was about ten times faster between days 13 and 18. Furthermore, leucine concentration was about 1.7 times higher on day 13. The present results suggest that the lowered protein concentration previously observed in the cerebellum of homozygous Gunn rats is ascribed to the increased rate of protein degradation on day 13, and to the decreased rate of protein synthesis on day 30.

References

May 15, 1979·The Biochemical Journal·J L Dahl, V J Weibel
Mar 1, 1979·Archives of Neurology·J Y Jew, D Sandquist
Jun 1, 1978·Journal of Neurochemistry·P Y Chee, J L Dahl
Mar 1, 1977·Journal of Neurochemistry·P Y Chee, J L Dahl
Feb 1, 1975·Journal of Neurochemistry·D S DunlopA Lajtha
Jul 1, 1967·Journal of Neuropathology and Experimental Neurology·H S Schutta, L Johnson
Aug 1, 1958·The Journal of Clinical Investigation·R SCHMIDR L SWARM

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