Ratio between estimated glomerular filtration rates of creatinine and cystatin C predicts overall survival in patients with hepatocellular carcinoma

Hepatology Research : the Official Journal of the Japan Society of Hepatology
Yasuyuki TamaiYoshiyuki Takei

Abstract

Hepatocellular carcinoma (HCC) patients with sarcopenia have a poor survival, but there are no predictive markers for survival relating to muscle mass and liver function. Therefore, we investigated whether the ratio between estimated glomerular filtration rates of serum creatinine (Scre) and serum cystatin C (Scys) (eGFRcre/eGFRcys) can be used as a predictive marker of survival in HCC patients. First, the correlation between Scre/Scys ratio and muscle mass was examined in 50 patients with chronic liver disease. Second, a change in Scre/Scys ratio relating to liver function was investigated in cirrhotic rats. Finally, the relationship between the eGFRcre/eGFRcys ratio and survival was assessed in 86 HCC patients. The Scre/Scys ratio was correlated with skeletal muscle mass index (r = 0.331, P = 0.019) and psoas muscle area index (r = 0.397, P = 0.004) in chronic liver disease patients. In cirrhotic rats, Scre and Scre/Scys ratio were decreased corresponding with liver function. Thirty-five of 86 HCC patients died within the average follow-up period of 35 months. The patients with an eGFRcre/eGFRcys ratio <1.26 had significantly longer rates of survival compared to patients with an eGFRcre/eGFRcys ratio ≥1.26 (28.8 vs. 18.5 mont...Continue Reading

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Citations

Feb 16, 2020·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Tatsuki IchikawaKazuhiko Nakao
Mar 19, 2019·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Masashi FujitaHiromasa Ohira
Jul 30, 2021·Clinical Endocrinology·Luciana Martel-DuguechElena Valassi
Aug 27, 2021·Journal of the American Medical Directors Association·Hiroshi KusunokiKen Shinmura

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