Ratio of circulating follistatin and activin A reflects the severity of acute liver injury and prognosis in patients with acute liver failure

Journal of Gastroenterology and Hepatology
Shi De LinKazuyuki Suzuki

Abstract

The activin A-follistatin system is known to play a critical role in hepatocyte regeneration during the repair of liver tissue. However, the relationship between blood levels of these compounds and the severity and prognosis of acute liver injury remains unclear. The aim of this study was to evaluate the clinical significance of circulating activin A and follistatin in patients with acute liver disease. Serum activin A and plasma follistatin levels were determined on admission by enzyme-linked immunosorbent assay in 32 patients with acute hepatitis (AH), 23 patients with acute severe hepatitis (ASH) and 16 patients with acute liver failure (ALF). Both serum activin A and plasma follistatin levels were significantly elevated in patients with ASH and ALF when compared with those in patients with AH and normal controls (NC). Although plasma follistatin levels were significantly and positively correlated with serum activin A levels (r = 0.413, P < 0.001), the follistatin and activin A (F/A) ratio showed distinct deviation from NC between AH and ALF patients. The F/A ratio in AH patients was significantly elevated when compared with NC, but was significantly reduced in ALF patients. Furthermore, the F/A ratio in non-surviving ALF pa...Continue Reading

References

Dec 30, 1976·The New England Journal of Medicine·S Sherlock
Oct 1, 1991·Proceedings of the Society for Experimental Biology and Medicine·L V DePaoloN Ling
Jun 1, 1991·Digestive Diseases and Sciences·R D HughesR Williams
Jun 1, 1989·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·H TsubouchiY Muto
Jul 18, 1970·Nature·B C Elford
Aug 1, 1993·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·R H SchwallT G Terrell
Sep 1, 1993·The Journal of Clinical Investigation·H YasudaI Kojima
Jan 15, 1996·Molecular and Cellular Endocrinology·J P de WinterA J van den Eijnden-van Raaij
Jun 1, 1997·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Y Q ZhangI Kojima
Oct 27, 1997·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·P J De BleserA Geerts
Apr 30, 1999·Molecular and Cellular Endocrinology·C E RussellD J Phillips
Mar 25, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·K KogureI Kojima
Oct 27, 2001·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·T IchikawaI Kojima
Sep 27, 2002·Experimental Biology and Medicine·Corrine WeltAlan Schneyer
Feb 1, 2003·European Journal of Gastroenterology & Hepatology·Robin D Hughes, Lee W Evans
Jan 24, 2004·Journal of Hepatology·William Bernal, Julia Wendon

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Citations

Jun 25, 2009·Human Reproduction·P FlorioF Petraglia
Nov 26, 2008·Clinica Chimica Acta; International Journal of Clinical Chemistry·Toru MiyoshiShozo Kusachi
Apr 18, 2012·Alimentary Pharmacology & Therapeutics·K A WlodzimirowR A F M Chamuleau
Sep 26, 2006·Mutation Research·Chantal Rodgarkia-DaraMichael Grusch
Oct 31, 2009·World Journal of Hepatology·Emanuel KreidlMichael Grusch
Nov 13, 2019·Current Opinion in Nephrology and Hypertension·Neel Mehta, Joan C Krepinsky
Oct 6, 2016·Experimental and Therapeutic Medicine·Yunfu LvHongfei Wu

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