Ratio of Creatine Kinase to Alanine Aminotransferase as a Biomarker of Acute Liver Injury in Dystrophinopathy

Disease Markers
Liang WangCheng Zhang

Abstract

To investigate the ratios of creatine kinase (CK) to aminotransferases as biomarkers of acute liver injury in dystrophinopathy. C57 and mdx (dystrophic) mice were treated with a hepatotoxic reagent D-galactosamine (D-GalN). The degrees of liver and muscle injury were assessed using histological examinations. To examine whether serum CK-adjusted aminotransferase levels could indicate liver status in dystrophic mice, the CK/alanine aminotransferase (ALT) and CK/aspartate aminotransferase (AST) ratios were analyzed. Furthermore, we enrolled 658 male patients with dystrophinopathy and 378 male patients without muscle and liver injury as control, whose serum ALT, AST, and CK levels were examined. Animal experiments indicated that D-GalN treatment could induce acute liver injury but not muscle injury. Additionally, D-GalN decreased the CK/ALT and CK/AST ratios in both C57 mice and mdx mice (P < 0.001). However, there was an overlap of the CK/AST ratio between dystrophic mice with and without acute liver injury. In patients with dystrophinopathy, CK-adjusted ALT diminished the variability associated with age, genotype, clinical phenotype, and motor function (P > 0.05). CK/ALT is a potential biomarker for the differential evaluation of...Continue Reading

References

Feb 8, 1975·Clinica Chimica Acta; International Journal of Clinical Chemistry·E Jockers-Wretou, G Pfleiderer
Nov 1, 1989·Journal of Medical Genetics·S HodgsonV Dubowitz
Jan 1, 1973·Journal of the Neurological Sciences·M A JohnsonD Appleton
Jun 26, 1999·Neuromuscular Disorders : NMD·J Forst, R Forst
May 4, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Sanjay B JadhaoSanjay B Jadaho
Feb 3, 2005·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Edoardo G GianniniVincenzo Savarino
Dec 31, 2005·Metabolic Brain Disease·Mireille Bélanger, Roger F Butterworth
Sep 4, 2007·British Journal of Clinical Pharmacology·Jonas PetterssonMats Ekelund
Jan 22, 2008·British Journal of Sports Medicine·A BessaL-C Cameron
Jan 22, 2008·Clinics in Sports Medicine·Paola BrancaccioFrancesco Mario Limongelli
Mar 21, 2008·Journal of Child Neurology·Xiomara Q RosalesJerry R Mendell
May 8, 2009·Journal of Pediatric Gastroenterology and Nutrition·Karan M Emerick
Jul 23, 2009·Muscle & Nerve·Laurence ViolletJerry R Mendell
Sep 22, 2009·Canadian Journal of Microbiology·Cecilia HaroGraciela Agüero
Feb 6, 2010·Current Opinion in Critical Care·Christopher BeckOlaf Picker
Mar 5, 2010·Cleveland Clinic Journal of Medicine·George Aragon, Zobair M Younossi
May 27, 2010·Journal of Paediatrics and Child Health·Claudio VeropalumboPietro Vajro
Jun 4, 2010·Clinical Chemistry and Laboratory Medicine : CCLM·Paola BrancaccioNicola Maffulli
Sep 22, 2010·Current Heart Failure Reports·Anitra Romfh, Elizabeth M McNally
Dec 15, 2010·Pediatrics·Hugh J McMillanPeter B Kang
Apr 5, 2013·The FEBS Journal·Terence A Partridge
Nov 13, 2013·Expert Review of Cardiovascular Therapy·Brian F BirnbaumCharles E Canter
Dec 7, 2013·Expert Opinion on Biological Therapy·Susan JarminGeorge Dickson
Feb 11, 2014·Pediatric Gastroenterology, Hepatology & Nutrition·Ki-Soo Kang
Apr 10, 2014·Biomarkers in Medicine·Irena A Rebalka, Thomas J Hawke
May 2, 2014·Neuromuscular Disorders : NMD·Jean K MahNathalie Jette
Aug 7, 2014·Tidsskrift for den Norske lægeforening : tidsskrift for praktisk medicin, ny række·Ellen J AnnexstadMagnhild Rasmussen
Feb 12, 2015·Journal of Muscle Research and Cell Motility·Jennifer Manning, Dervla O'Malley
Feb 19, 2015·Evidence-based Complementary and Alternative Medicine : ECAM·Min-Kyung ChoiChang-Gue Son
Jun 13, 2015·Disease Markers·Yuling ZhuCheng Zhang
Sep 30, 2015·Proceedings of the National Academy of Sciences of the United States of America·Nicholas P WhiteheadStanley C Froehner
Jan 14, 2016·Cleveland Clinic Journal of Medicine·Siamak Moghadam-KiaRohit Aggarwal
Feb 27, 2018·Npj Regenerative Medicine·Nora YucelHelen M Blau

❮ Previous
Next ❯

Citations

Apr 23, 2019·PloS One·Túlio de Almeida HermesElaine Minatel
Mar 25, 2020·World Journal of Gastroenterology : WJG·Andy Kh Lim
Dec 10, 2020·International Journal of Experimental Pathology·Maria Laura Jorge MichelettoDavid Feder
Jan 9, 2021·Stem Cell Research & Therapy·Liang WangCheng Zhang
Jan 22, 2022·Nucleic Acids Research·Pachamuthu KandasamyChandra Vargeese

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsy
genotyping

Software Mentioned

GraphPad PRISM
SPSS

Related Concepts

Related Feeds

© 2022 Meta ULC. All rights reserved