Ratio of transmitral early filling velocity to early diastolic strain rate predicts outcomes in patients with systolic heart failure

European Heart Journal Cardiovascular Imaging
Yi-Hsin ChanChi-Tai Kuo

Abstract

The ratio of transmitral early filling velocity (E) to early diastolic tissue velocity (E') is a key diastolic function parameter. The early diastolic strain rate (E'sr) has been proposed as a substitute for E' in the E/E' ratio for better estimation of left ventricular (LV) filling pressure. This study aims to assess the predictive value of combined E/E'sr ratio and global longitudinal strain (GLS) for prognosis in systolic heart failure (SHF). We retrospectively analysed 330 SHF patients with an LV ejection fraction (LVEF) ≤ 40%. Study end points were defined as all-cause mortality or heart transplantation. The incremental value of GLS and the E/E'sr ratio over LVEF and E/E' for outcome prediction was assessed using nested Cox models. Ninety-nine (30%) patients reached the end point over a median follow-up of 46 months. Baseline variables associated with outcomes were age, glomerular filtration rate, pulmonary artery systolic pressure, and LV end-systolic volume index. After multivariate adjustment, GLS (hazard ratio: 1.48, P = 0.025) and the E/E'sr ratio (hazard ratio: 1.41, P = 0.002) were both independent predictors. LVEF or E/E' was not an independent predictor when GLS and E/E'sr were included in the model. Patients with...Continue Reading

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Citations

Oct 27, 2017·European Heart Journal Cardiovascular Imaging·Thor EdvardsenBogdan A Popescu
Jul 23, 2019·European Heart Journal Cardiovascular Imaging·Mats Christian Højbjerg LassenPeter Godsk Jørgensen
Nov 28, 2017·Echocardiography·Matthew F GottbrechtGerard P Aurigemma
Aug 8, 2018·European Heart Journal Cardiovascular Imaging·Thor EdvardsenBogdan A Popescu
Dec 24, 2019·Hellenic Journal of Cardiology : HJC = Hellēnikē Kardiologikē Epitheōrēsē·Eleni S NakouFragiskos I Parthenakis

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