Ratiometric Biosensor for Aggregation-Induced Emission-Guided Precise Photodynamic Therapy

ACS Nano
Kai HanXian-Zheng Zhang

Abstract

Photodynamic therapy faces the barrier of choosing the appropriate irradiation region and time. In this paper, a matrix metalloproteinase-2 (MMP-2) responsive ratiometric biosensor was designed and synthesized for aggregation-induced emission (AIE)-guided precise photodynamic therapy. It was found that the biosensor presented the MMP-2 responsive AIE behavior. Most importantly, it could accurately differentiate the tumor cells from the healthy cells by the fluorescence ratio between freed tetraphenylethylene and protoporphyrin IX (PpIX, internal reference). In vivo study demonstrated that the biosensor could preferentially accumulate in the tumor tissue with a relative long blood retention time. Note that the intrinsic fluorescence of PpIX and MMP-2-triggered AIE fluorescence provided a real-time feedback which guided precise photodynamic therapy in vivo efficiently. This strategy demonstrated here opens a window in the precise medicine, especially for phototherapy.

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Citations

Dec 5, 2015·ACS Applied Materials & Interfaces·Shi-Ying LiXian-Zheng Zhang
Sep 7, 2016·ACS Applied Materials & Interfaces·Kai HanHe-You Han
Oct 11, 2016·Chemical Society Reviews·Wenpei FanXiaoyuan Chen
Jul 22, 2017·Physical Chemistry Chemical Physics : PCCP·Jon UrangaDavid Casanova
Mar 24, 2018·Chemical Society Reviews·Xiaolin HuangXiaoyuan Chen
Jun 2, 2018·Nanoscale·Haozhe HeXintao Shuai
Jan 3, 2019·Chemistry : a European Journal·Sheng XieBen Zhong Tang
Sep 22, 2017·Current Medicinal Chemistry·Houjuan ZhuKanyi Pu
Feb 28, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Bin LiJinfeng Xing
Nov 14, 2018·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Chuanqing Lan, Shulin Zhao
Jan 7, 2018·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Kai HanHeyou Han
Mar 1, 2017·Chemical Science·Chen GuiBen Zhong Tang

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