Rational application of drug promiscuity in medicinal chemistry

Future Medicinal Chemistry
Yicheng Mei, Baowei Yang

Abstract

'Drug promiscuity' refers to a drug that can act on multiple molecular targets, exhibiting similar or different pharmacological effects. Drugs may interact with unwanted targets, leading to off-target effects (one of the main reasons for side effects). Thus, intervention to prevent off-target effects in the early stages of drug discovery could reduce the risk of failure. The conversion between target and off-target effects is important for drug repurposing. Drug repurposing strategies could reduce research and development costs. This review details the research progress in the rational application of drug promiscuity for the discovery of multi-target drugs, drug repurposing and improving druggability in medicinal chemistry over the last 5 years.

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Citations

Jul 13, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Natacha CerisierAnne-Claude Camproux
Nov 9, 2019·Future Medicinal Chemistry·Li-Wen XiaYong-Tao Duan
Jun 9, 2019·BMC Research Notes·Zackary FallsRam Samudrala
Sep 13, 2020·Biological Reviews of the Cambridge Philosophical Society·Munishwar Nath Gupta, Ipsita Roy
Jul 3, 2019·International Journal of Molecular Sciences·Alejandro Valdés-JiménezMiguel Reyes-Parada
Dec 4, 2019·Journal of Computer-aided Molecular Design·Filip Miljković, Jürgen Bajorath
Jun 21, 2019·Medicinal Research Reviews·Daniela TomaselliAntonello Mai
Nov 24, 2020·Organic & Biomolecular Chemistry·Haixia LiuBiao Jiang
May 29, 2021·Journal of Computer-aided Molecular Design·Thomas Blaschke, Jürgen Bajorath
May 29, 2021·RSC Medicinal Chemistry·Dagmar StumpfeJürgen Bajorath

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Methods Mentioned

BETA
NMR
x-ray crystallography

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