Rational combinations of immunotherapy with radiotherapy in ovarian cancer

The Lancet Oncology
Fernanda G HerreraGeorge Coukos

Abstract

Except for its use in palliative care, radiotherapy has been largely abandoned in the management of ovarian cancer because of the recognised efficacy and lower toxicity of systemic chemotherapy compared with radiotherapy. New data have emerged that show synergy of radiotherapy with immunotherapy to control or eradicate cancer. Different doses of hypofractionated radiotherapy have been shown to induce immunogenic cell death and in-situ vaccination in several tumour models. However, doses less than 2 Gy can also reprogramme the tumour microenvironment. This Series paper discusses the past and present use of radiotherapy for ovarian cancer, and the mechanisms by which radiotherapy can mobilise anticancer immunity. We provide emerging preclinical and clinical data for combining immunotherapy with radiotherapy for ovarian cancer treatment and offer a clinical development roadmap to guide the next generation of clinical trials for this combination strategy for this disease.

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Citations

Feb 6, 2021·Journal of Cellular and Molecular Medicine·Fang WangJinquan Cui
Oct 31, 2020·Frontiers in Immunology·Chang YangWei-Lin Jin
Feb 29, 2020·Current Opinion in Biotechnology·Evripidis LanitisMelita Irving
Sep 4, 2020·Current Opinion in Biotechnology·Maria Ochoa de OlzaFernanda G Herrera
Jul 20, 2020·International Immunopharmacology·Milad AshrafizadehMasoud Najafi
Mar 31, 2021·British Journal of Cancer·Matteo MorottiAhmed A Ahmed
Apr 10, 2021·Cellular Oncology (Dordrecht)·Jamal Majidpoor, Keywan Mortezaee
May 1, 2021·Cancers·Alice IndiniGiorgio Bogani
Jun 8, 2021·Frontiers in Oncology·Chen ZhangXiaodong Liu
Aug 8, 2021·Cancers·Diana ŽilovičSonata Jarmalaitė
Sep 1, 2021·Journal of Biochemical and Molecular Toxicology·Masoud NajafiKeywan Mortezaee
Sep 16, 2020·Seminars in Cancer Biology·Olivia Le SauxS Intidhar Labidi-Galy

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