Rational design of a ratiometric two-photon fluorescent probe for real-time visualization of apoptosis

Chemical Communications : Chem Comm
Yinliang HuangXiangming Meng

Abstract

A dialdehyde-functionalized ratiometric two-photon fluorescent probe (Mito-DCHO) based on a symmetric carbazole-containing two-dimensional ICT system was rationally designed for cysteine-specific detection in mitochondria, which was utilized for real-time assessing and dual-channel visualization of the early stage of apoptosis by monitoring mitochondrial oxidative stress levels.

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Citations

Nov 20, 2018·Chemical Communications : Chem Comm·Samira Husen Alamudi, Young-Tae Chang
Nov 2, 2019·Organic & Biomolecular Chemistry·Hui ZhangXiangzhi Song
Jun 15, 2019·Chembiochem : a European Journal of Chemical Biology·Shuai XiaHaiying Liu
Aug 1, 2021·Bioorganic & Medicinal Chemistry Letters·Chen ShaoGuofan Jin
Jul 16, 2019·Analytical Chemistry·Minggang TianWeiying Lin

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Methods Mentioned

BETA
NMR
flow cytometry
Fluorescence

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis