Rational design of an "all-in-one" phototheranostic.

Chemical Science
Zi-Shu YangJun-Long Zhang

Abstract

We report here porphodilactol derivatives and their corresponding metal complexes. These systems show promise as "all-in-one" phototheranostics and are predicated on a design strategy that involves controlling the relationship between intersystem crossing (ISC) and photothermal conversion efficiency following photoexcitation. The requisite balance was achieved by tuning the aromaticity of these porphyrinoid derivatives and forming complexes with one of two lanthanide cations, namely Gd3+ and Lu3+. The net result led to a metalloporphodilactol system, Gd-trans-2, with seemingly optimal ISC efficiency, photothermal conversion efficiency and fluorescence properties, as well as good chemical stability. Encapsulation of Gd-trans-2 within mesoporous silica nanoparticles (MSN) allowed its evaluation for tumour diagnosis and therapy. It was found to be effective as an "all-in-one" phototheranostic that allowed for NIR fluorescence/photoacoustic dual-modal imaging while providing an excellent combined PTT/PDT therapeutic efficacy in vitro and in vivo in 4T1-tumour-bearing mice.

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Citations

Aug 28, 2020·ChemPlusChem·Guo-Qing JinJun-Long Zhang
Sep 26, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Damaris ThuitaChristian Brückner
May 12, 2021·Journal of the American Chemical Society·Mengliang ZhuJun-Long Zhang
Jul 1, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Lu LiYue Wang

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Methods Mentioned

BETA
phosphorescence imaging
Fluorescence
electron paramagnetic resonance
fluorescence microscopy
flow cytometry
fluorescence imaging

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