Rational design of hybridization chain reaction monomers for robust signal amplification

Chemical Communications : Chem Comm
Yan Shan Ang, Lin-Yue Lanry Yung

Abstract

We established four-point guidelines for the sequence design of hairpin monomers in hybridization chain reaction (HCR). This enabled greater flexibility to customize specific hairpin sequences for use with the readout platform of interest. Using shorter hairpin stem length, a one-pot signal amplification system was demonstrated by incorporating distance-sensitive Förster resonance energy transfer (FRET) readout.

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Citations

May 22, 2016·Nucleic Acids Research·Yan Shan AngLin-Yue Lanry Yung
Jun 2, 2017·Luminescence : the Journal of Biological and Chemical Luminescence·Xianjiu LiaoZuliang Huang
Jan 12, 2019·Chembiochem : a European Journal of Chemical Biology·Takashi Sakamoto, Rikuto Yamada
Jun 21, 2019·ELife·Martin H FabryBenjamin Czech
May 28, 2020·Chembiochem : a European Journal of Chemical Biology·Yan Shan AngLin-Yue Lanry Yung
Jun 2, 2020·Frontiers in Molecular Neuroscience·Yousuke Tsuneoka, Hiromasa Funato
Jul 6, 2018·Macromolecular Rapid Communications·Laura A Lanier, Harry Bermudez
Mar 21, 2021·Nature Communications·Dionis MinevWilliam M Shih
Apr 14, 2021·Nucleic Acids Research·Yan Shan Ang, Lin-Yue Lanry Yung
Jul 2, 2021·Chemical Science·Ki Tae KimNicolas Winssinger
Aug 9, 2021·Talanta·Jingting WuZai-Sheng Wu
May 2, 2020·Journal of the American Chemical Society·C Adrian FiggChad A Mirkin
Jul 11, 2018·Journal of the American Chemical Society·Wouter EngelenMaarten Merkx

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