Rational Design of Metal Organic Framework Nanocarrier-Based Codelivery System of Doxorubicin Hydrochloride/Verapamil Hydrochloride for Overcoming Multidrug Resistance with Efficient Targeted Cancer Therapy

ACS Applied Materials & Interfaces
Huiyuan ZhangYuxia Luan

Abstract

Conventional organic and inorganic drug nanocarriers suffer from serious drawbacks such as low drug-storage capacity and uncontrolled release. Moreover, multidrug resistance (MDR) has been one of the primary causes leading to chemotherapy failure for cancers. The main reason for MDR is the overexpressed active efflux transporters such as P-glycoprotein. Here, zeolitic imidazolate framework ZIF-8, as one of the biocompatible metal organic frameworks (MOFs), is reported for the first time as the multidrug carrier to realizing the efficient codelivery of verapamil hydrochloride (VER) as the P-glycoprotein inhibitor as well as doxorubicin hydrochloride (DOX) as an anticancer drug to overcome the MDR in addition to realize the active targeted ability for an efficient anticancer effect. Uniform ZIF-8 nanoparticles encapsulating DOX and VER are achieved by a facile one-pot process, in which the VER is used to overcome the multidrug resistance. Furthermore, methoxy poly(ethylene glycol)-folate (PEG-FA) is used to stabilize the (DOX+VER)@ZIF-8 to realize prolonged circulations and an active targeting drug delivery. In particular, the ZIF-8 exhibits high drug loading content up to ∼40.9% with a pH-triggered release behavior. Importantly,...Continue Reading

References

Jun 27, 2006·Proceedings of the National Academy of Sciences of the United States of America·Kyo Sung ParkOmar M Yaghi
Aug 10, 2006·Angewandte Chemie·Patricia HorcajadaGérard Férey
May 6, 2008·Journal of the American Chemical Society·Patricia HorcajadaGérard Férey
Jan 6, 2011·Chemical Communications : Chem Comm·Yichang PanZhiping Lai
Jan 18, 2011·Advanced Drug Delivery Reviews·L BildsteinP Couvreur
May 9, 2012·Journal of Controlled Release : Official Journal of the Controlled Release Society·Rita Nieto MontesinosAlf Lamprecht
May 15, 2012·Dalton Transactions : an International Journal of Inorganic Chemistry·Chun-Yi SunEn-Bo Wang
Nov 15, 2012·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Koldo UrbiolaConchita Tros de Ilarduya
Jan 3, 2013·Journal of Biomedical Materials Research. Part a·Yanfang SunJianbiao Ma
Jan 12, 2013·Journal of Controlled Release : Official Journal of the Controlled Release Society·Wei ChenZhiyuan Zhong
Jan 26, 2013·Journal of Photochemistry and Photobiology. B, Biology·Supriya SrinivasanAnthony J McGoron
Feb 5, 2013·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Jian-Min ShenFeng Yue
Feb 21, 2014·International Journal of Molecular Sciences·Yan ChenXiang-Rong Song
May 3, 2014·Journal of the American Chemical Society·Guhuan LiuShiyong Liu
Dec 3, 2014·Nanomedicine : Nanotechnology, Biology, and Medicine·Ying WangSiling Wang
Jan 20, 2015·Biotechnology Advances·Alejandro Sosnik, Maya Menaker Raskin
Feb 17, 2015·Journal of Advanced Research·Hossam M AbdallahAli M El-Halawany
Sep 29, 2015·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Danielle MortonLuke Theogarajan
Jan 1, 2016·ACS Applied Materials & Interfaces·Wing-Fu LaiAndrey L Rogach
Mar 2, 2016·Langmuir : the ACS Journal of Surfaces and Colloids·Luciane Franca de OliveiraMateus Borba Cardoso
Mar 13, 2016·Journal of Controlled Release : Official Journal of the Controlled Release Society·Kyungim KimSoon Hong Yuk
Dec 14, 2015·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Mengni HeQianwang Chen

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Citations

Jun 8, 2018·Advanced Materials·Teresa Simon-YarzaChristian Serre
Aug 10, 2018·Small·Mónica Giménez-MarquésPatricia Horcajada
Mar 14, 2019·Nanoscale·Hadi Ranji-BurachalooGreg G Qiao
May 14, 2019·Environmental Science and Pollution Research International·Carmen RaclesVasile Cozan
Jul 30, 2019·Advanced Materials·Peng MiKazunori Kataoka
Feb 7, 2018·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Lei WangZhigang Xie
Mar 31, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Gongsen ChenJian Ni
Nov 13, 2019·Lab on a Chip·Guocheng FangGungun Lin
Jan 10, 2019·Evidence-based Complementary and Alternative Medicine : ECAM·Xin LengJian Ni
Oct 3, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Xin LengJian Ni
Jan 18, 2020·Angewandte Chemie·Isabel Abánades LázaroRoss S Forgan
Dec 2, 2020·Nanomaterials·Seyed Dariush TaherzadePatricia Horcajada
Jan 5, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Bruna G CarvalhoLucimara G de la Torre
Dec 24, 2019·Seminars in Cancer Biology·Mohammed Razeeth Shait MohammedMohammad Imran Khan
Mar 3, 2021·Langmuir : the ACS Journal of Surfaces and Colloids·Xuebin MaJingcheng Hao
Jun 20, 2019·Current Medicinal Chemistry·Jian CaoHongqi Tian
Apr 17, 2021·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Ya-Xuan ZhuFu-Gen Wu
May 16, 2021·Toxicology and Applied Pharmacology·Alireza HashemzadehMajid Khazaei
May 16, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·Shangui LiuGuangxi Zhai
Jul 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Chenhao HuZhichao Pei
Aug 13, 2021·Langmuir : the ACS Journal of Surfaces and Colloids·Heze GuoHongjing Dou

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