Rational Design of Mimic Multienzyme Systems in Hierarchically Porous Biomimetic Metal-Organic Frameworks

ACS Applied Materials & Interfaces
Xiao LiuZhimin He

Abstract

A facile approach was reported to establish mimic multienzyme systems with hierarchically porous (HP) biomimetic metal-organic frameworks (MOFs) and natural enzymes for tandem catalysis. The hierarchically porous MOF HP-PCN-224(Fe) with peroxidase-like activity and tunable hierarchical porosity was synthesized via a modulator-induced strategy. HP-PCN-224(Fe) not only acts as the enzyme-immobilization matrix but also as an effective enzyme mimic, which could cooperate with the immobilized natural enzyme to catalyze the cascade reactions. The mimic multienzyme systems were used for the efficient colorimetric detection of a series of biomolecules, including glucose and uric acid. This work displays the great potential to construct highly functional biocatalysts by integrating the merits of both natural enzymes and MOF mimics, which are promising for applications in biosensing and biomimetic catalysis.

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Citations

May 24, 2019·Chemical Communications : Chem Comm·Daiwu LinZhimin He
Jan 5, 2020·Angewandte Chemie·Siming HuangGangfeng Ouyang
Jul 29, 2020·Dalton Transactions : an International Journal of Inorganic Chemistry·Nian ZhaoHongming He
Aug 19, 2020·Dalton Transactions : an International Journal of Inorganic Chemistry·Amarajothi DhakshinamoorthyHermenegildo Garcia
Jul 23, 2020·Frontiers in Bioengineering and Biotechnology·Huan XiaYanbin Jiang
Jun 28, 2020·Journal of Colloid and Interface Science·Xiaolin NieQufu Wei
Apr 25, 2021·Advanced Materials·Weiqing XuChengzhou Zhu
Apr 20, 2021·Journal of Hazardous Materials·Xiaolin NieQufu Wei
May 11, 2021·ACS Applied Materials & Interfaces·Huan XiaYanbin Jiang
Aug 1, 2019·ACS Applied Materials & Interfaces·Zhongyuan RenYinhua Wan
Oct 2, 2020·ACS Central Science·Xiaoliang WangShengqian Ma
Jan 9, 2021·ACS Applied Materials & Interfaces·Xiaolin NieQufu Wei
Sep 9, 2021·ACS Biomaterials Science & Engineering·Xun LiuKun Qian
Oct 15, 2021·Biomaterials Science·Di LiHongwei Duan
Nov 24, 2021·ACS Applied Materials & Interfaces·Cuie Wang, Kaiming Liao
Jan 14, 2022·Chembiochem : a European Journal of Chemical Biology·Wei HuangGangfeng Ouyang

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