PMID: 9184927Apr 1, 1997Paper

Rational design of nematode vaccines: hidden antigens

International Journal for Parasitology
E A Munn

Abstract

Hidden antigens are defined and the general validity of the hidden antigen approach is considered. Approaches to the problem of identifying hidden antigens are offered. The nature of the immune responses induced by injection of hidden antigens and their value in giving protection is considered in the light of the site of the hidden antigen in vivo. Particular attention is given to the value of integral membrane ectoenzymes as protective hidden antigens. The need to generate hidden antigens as recombinant proteins and the possibilities and problems associated with linear, conformational and carbohydrate epitopes are outlined. Finally, concerns about the lack of stimulation of induced immune responses and the risks of resistance developing are addressed.

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Citations

Mar 25, 2000·International Journal for Parasitology·R B Gasser, S E Newton
Oct 12, 2000·International Journal for Parasitology·M D WinterD L Lee
Aug 1, 1996·International Journal for Parasitology·P J Waller, M Faedo
Feb 27, 1999·International Journal for Parasitology·R K Bain
Feb 27, 1999·International Journal for Parasitology·W D Smith
Sep 29, 1999·International Journal for Parasitology·D N Onah, D Wakelin
Oct 17, 2006·Parasitology Today·M J Doenhoff
Aug 23, 2001·Veterinary Parasitology·R Prichard, A Tait
Jul 28, 1999·Veterinary Parasitology·A J Nisbet, P F Billingsley
Jul 21, 2005·New Zealand Veterinary Journal·W R HeinA C Heath
Apr 22, 2009·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Mark S PearsonAlex Loukas
Dec 3, 1999·Immunological Reviews·R M MaizelsM Yazdanbakhsh
Jul 17, 1999·Parasitology Today·R C Thompson
Nov 2, 2015·Applied Microbiology and Biotechnology·Jerica SabotičMarkus Künzler
Oct 27, 2015·EBioMedicine·Sasisekhar Bennuru
Jul 21, 2011·Parasite Immunology·Samantha E EllisJ B Matthews
Jun 6, 2006·Veterinary Parasitology·Frank Jackson, Jim Miller
Apr 5, 2003·Journal of Veterinary Medicine. B, Infectious Diseases and Veterinary Public Health·J M AlundaM Cuquerella
Jul 16, 2010·Veterinary Medicine International·Leticia García-CoiradasMontserrat Cuquerella
Mar 13, 2014·Expert Review of Vaccines·James P Hewitson, Rick M Maizels
Feb 24, 2001·Annals of the New York Academy of Sciences·R D Melendez

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