Rational design of new materials using recombinant structural proteins: Current state and future challenges

Journal of Structural Biology
Tara D SutherlandTrevor D Rapson

Abstract

Sequence-definable polymers are seen as a prerequisite for design of future materials, with many polymer scientists regarding such polymers as the holy grail of polymer science. Recombinant proteins are sequence-defined polymers. Proteins are dictated by DNA templates and therefore the sequence of amino acids in a protein is defined, and molecular biology provides tools that allow redesign of the DNA as required. Despite this advantage, proteins are underrepresented in materials science. In this publication we investigate the advantages and limitations of using proteins as templates for rational design of new materials.

Citations

Sep 22, 2018·PloS One·Tara D SutherlandGavin A Huttley
Apr 16, 2019·Journal of Biomedical Materials Research. Part a·Tara D SutherlandJerome A Werkmeister
Jun 25, 2020·Small·Hèctor López-LagunaEsther Vázquez
Mar 1, 2020·Scientific Reports·Trevor D RapsonTara D Sutherland
Feb 18, 2021·The Journal of Physical Chemistry. B·Romeo C A DubiniPetra Rovó
Jul 28, 2018·Biomacromolecules·Julieta M SánchezAntonio Villaverde

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