Rational ligand choice extends the SABRE substrate scope.

Chemical Communications : Chem Comm
Johannes F P ColellThomas Theis

Abstract

Here we report on chelating ligands for Signal Amplification By Reversible Exchange (SABRE) catalysts that permit hyperpolarisation on otherwise sterically hindered substrates. We demonstrate 1H enhancements of ∼100-fold over 8.5 T thermal for 2-substituted pyridines, and smaller, yet significant enhancements for provitamin B6 and caffeine. We also show 15N-enhancements of ∼1000-fold and 19F-enhancements of 30-fold.

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Citations

Sep 2, 2020·Scientific Reports·Hye Jin JeongKeunhong Jeong
Nov 17, 2020·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Ben J TicknerSimon B Duckett
Jan 29, 2021·Dalton Transactions : an International Journal of Inorganic Chemistry·Ben J TicknerGoran Angelovski
Apr 20, 2021·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Thomas B R RobertsonRyan E Mewis
Sep 23, 2021·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Kailai LinVolker Blum

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Methods Mentioned

BETA
NMR

Software Mentioned

aims
FHI
SABRE

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