Rational strain improvement for surfactin production: enhancing the yield and generating novel structures

Microbial Cell Factories
Fangxiang HuShuang Li

Abstract

Surfactin, one of the most powerful microbial surfactants, is a lipopeptide-type biosurfactant which combines interesting physicochemical properties and biological activities. However, the high cost caused by its low productivity largely limits the commercial application of surfactin. Hence, many engineered bacterium have also been used to enhance surfactin biosynthesis. This review briefly summarizes the mechanism of surfactin biosynthesis, highlighting the synthesis pathway of N-terminally attached fatty acids, and outlines the main genetic engineering strategies for improving the yield and generating novel structures of surfactin, including promoter engineering, enhancing efflux systems, modifying the transcriptional regulatory genes of surfactin synthase (srfA), genomics and transcriptomics analysis, non ribosomal peptide synthetase (NRPS) domain and combinatorial biosynthesis. Finally, we discuss the future prospects of the research on surfactin.

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Citations

Feb 28, 2020·International Journal of Environmental Research and Public Health·Deepti MalviyaG P Brahmaprakash
Aug 30, 2020·International Journal of Molecular Sciences·Syahir HabibNur Adeela Yasid
Oct 31, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Muhammad Fazle Rabbee, Kwang-Hyun Baek
Feb 12, 2021·Colloids and Surfaces. B, Biointerfaces·Fangxiang HuShuang Li
Mar 20, 2021·Frontiers in Bioengineering and Biotechnology·Ariane ThéatrePhilippe Jacques
Jul 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Tomasz JanekZbigniew Lazar
Jul 27, 2021·Bioresource Technology·Zhiwen ZhuBing Chen
Sep 16, 2020·Journal of Agricultural and Food Chemistry·Dandan ZouZhihong Xin
Sep 18, 2021·Analytical Chemistry·Daniel PetrasMingxun Wang

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Methods Mentioned

BETA
genetic modification
dissection
acylation

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