PMID: 16533473Mar 15, 2006Paper

Rationale and appropriate use of chemotherapy and radiotherapy for pancreatic ductal adenocarcinoma

Current Gastroenterology Reports
Robert de W Marsh, Thomas George

Abstract

The emergence of effective systemic chemotherapy, along with the parallel development of new targeted cell signal inhibitors for pancreatic cancer treatment, has provided impetus for a re-examination of the appropriate use of chemotherapy and radiation therapy in this malignancy. In addition to exciting developments in the treatment of locally advanced and metastatic disease, new data have emerged regarding the efficacy of adjuvant and neoadjuvant therapy when combined with traditional surgical approaches such as a Whipple procedure. This review summarizes the sentinel clinical trials and discoveries that have influenced the development and deployment of scientifically based multidisciplinary care for today's patients, with a particular focus on modern radiation and chemotherapy.

References

Oct 1, 1991·International Journal of Radiation Oncology, Biology, Physics·J E TepperG E Hanks
Dec 1, 1991·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J A DeCaprioS G Arbuck
Feb 1, 1988·The American Journal of the Medical Sciences·R HansenT Anderson
Nov 1, 1995·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·M MohiuddinR Cantor
Jan 1, 1993·American Journal of Surgery·R J Geer, M F Brennan
Jan 1, 1993·Cancer Treatment Reviews·B LundH H Hansen
Mar 1, 1996·International Journal of Radiation Oncology, Biology, Physics·T S LawrenceD S Shewach
Apr 1, 1996·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M L RothenbergD D Von Hoff
Aug 1, 1996·Annals of Oncology : Official Journal of the European Society for Medical Oncology·B GlimeliusC Svensson
Dec 1, 1996·International Journal of Radiation Oncology, Biology, Physics·S E OrderP E Wallner
Mar 1, 1997·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·F R SpitzD B Evans
Jun 1, 1997·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·H A BurrisD D Von Hoff
Jan 24, 1998·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J P HoffmanA B Benson
Feb 7, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·A EisbruchT S Lawrence
Apr 5, 2001·International Journal of Radiation Oncology, Biology, Physics·H SafranH Wanebo
Jun 8, 2001·International Journal of Radiation Oncology, Biology, Physics·M ReniV Di Carlo
Nov 13, 2001·International Journal of Radiation Oncology, Biology, Physics·A A YavuzF Ozdemir
Nov 22, 2001·Lancet·J P NeoptolemosUNKNOWN European Study Group for Pancreatic Cancer
Jan 5, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Thomas H CartwrightJoseph J Schulz
Apr 17, 2002·International Journal of Radiation Oncology, Biology, Physics·Christopher H CraneN A Janjan
Jun 5, 2002·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·S M de LangeG Giaccone
Aug 1, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jordan D BerlinAl Bowen Benson
Aug 17, 2002·International Journal of Radiation Oncology, Biology, Physics·Howard SafranTyvin Rich
Sep 10, 2002·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·V MoutardierJ R Delpero
Feb 8, 2003·International Journal of Radiation Oncology, Biology, Physics·H AshamallaP Ross
Feb 11, 2003·American Journal of Clinical Oncology·Javier AristuIgnacio Azinovic
Mar 26, 2003·International Journal of Radiation Oncology, Biology, Physics·Valerie MagninJean Robert Delpero
May 3, 2003·American Journal of Surgery·Vincent J PicozziL William Traverso
Jun 28, 2003·International Journal of Radiation Oncology, Biology, Physics·Jean-Luc Van LaethemJean Closset
Jul 30, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Margaret TemperoJames Abbruzzese
Aug 12, 2003·International Journal of Radiation Oncology, Biology, Physics·Chung-Pin LiSang-Hue Yen
Sep 26, 2003·Pancreas·F ViretM Giovannini
Dec 10, 2003·American Journal of Clinical Oncology·Sana Al-SukhunAnthony F Shields
Mar 19, 2004·The New England Journal of Medicine·John P NeoptolemosUNKNOWN European Study Group for Pancreatic Cancer

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Citations

Jan 1, 2008·HPB Surgery : a World Journal of Hepatic, Pancreatic and Biliary Surgery·Olga N Tucker, Mohamed Rela
May 30, 2007·Gastroenterology Clinics of North America·Jan FrankoA James Moser
Jul 17, 2008·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Naomi Y JiangDi Lu

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