Rationale and design for the Vascular Outcomes study of ASA along with rivaroxaban in endovascular or surgical limb revascularization for peripheral artery disease (VOYAGER PAD)

American Heart Journal
Warren H CapellWilliam R Hiatt

Abstract

Patients with peripheral artery disease (PAD) undergoing a lower-extremity revascularization are at heightened risk for ischemic cardiac and limb events. Although intensification of antithrombotic therapy after revascularization has demonstrated benefit in coronary disease populations, this approach has not been well studied or shown consistent benefit in PAD. Recent trial evidence demonstrated that a treatment strategy of rivaroxaban added to background antiplatelet therapy reduced ischemic risk in patients following recent acute coronary syndromes, as well as in patients with stable atherosclerotic vascular disease. Whether these benefits extend to the population of patients with symptomatic lower-extremity PAD undergoing revascularization is the objective of the VOYAGER PAD trial. VOYAGER PAD is an international randomized, double-blind, placebo-controlled trial to evaluate the efficacy and safety of rivaroxaban in symptomatic PAD patients undergoing a peripheral surgical and/or endovascular revascularization. Patients are randomized in a 1:1 ratio to either rivaroxaban 2.5 mg twice daily or placebo, on a background of low-dose aspirin (100 mg daily). In addition, the use of a limited course of P2Y12 inhibition is allowed at...Continue Reading

References

Jul 1, 1995·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·D BergqvistJ P Dickinson
May 10, 2000·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·B GirolamiH R Büller
Jun 6, 2000·JAMA : the Journal of the American Medical Association·P DurieuxE Lepage
Jan 16, 2007·Journal of Vascular Surgery·L NorgrenUNKNOWN TASC II Working Group
Jul 20, 2007·The New England Journal of Medicine·UNKNOWN Warfarin Antiplatelet Vascular Evaluation Trial InvestigatorsGilbert Gosselin
Dec 14, 2007·The New England Journal of Medicine·Giovanni Davì, Carlo Patrono
Nov 15, 2011·The New England Journal of Medicine·Jessica L MegaUNKNOWN ATLAS ACS 2–TIMI 51 Investigators
Apr 6, 2016·Journal of the American College of Cardiology·Marc P BonacaMarc S Sabatine
Nov 15, 2016·Circulation·W Schuyler JonesUNKNOWN International Steering Committee and Investigators of the EUCLID Trial
Dec 14, 2016·The New England Journal of Medicine·William R HiattUNKNOWN EUCLID Trial Steering Committee and Investigators
Aug 29, 2017·The New England Journal of Medicine·John W EikelboomUNKNOWN COMPASS Investigators

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Citations

Oct 4, 2019·VASA. Zeitschrift für Gefässkrankheiten·Ulrich FrankJill Belch
Dec 4, 2019·VASA. Zeitschrift für Gefässkrankheiten·Ulrich FrankPiotr Terlecki
Mar 5, 2020·Expert Review of Cardiovascular Therapy·Stefanos Giannopoulos, Ehrin J Armstrong
Jul 9, 2020·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Joshua C VogtJoaquin E Cigarroa
Jul 17, 2020·Arteriosclerosis, Thrombosis, and Vascular Biology·Nupoor NarulaNavneet Narula
Feb 26, 2019·Vascular Medicine·Eric KaplovitchSonia S Anand
Jan 31, 2020·Current Cardiology Reports·Nicholas GovsyeyevMarc P Bonaca
Jan 3, 2019·European Heart Journal·Victor AboyansUNKNOWN ESC Working Group on Aorta and Peripheral Vascular Diseases
Dec 14, 2018·Current Opinion in Cardiology·Mohamad A HussainMohammed Al-Omran
Jul 30, 2019·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Christian BradaricTareq Ibrahim
Jun 27, 2019·Circulation·Connie N HessWilliam R Hiatt
Mar 30, 2020·The New England Journal of Medicine·Marc P BonacaWilliam R Hiatt
Sep 27, 2018·Nature Reviews. Cardiology·Giuseppe PattiUNKNOWN Working Group on Thrombosis of the Italian Society of Cardiology
Nov 7, 2019·Vascular Medicine·Stefanos Giannopoulos, Ehrin J Armstrong
Feb 8, 2020·Journal of the American College of Cardiology·Jeffrey W Olin, Hillary Johnston-Cox
Feb 16, 2021·Vascular Medicine·Stefanos Giannopoulos, Ehrin J Armstrong
Mar 6, 2021·Journal of Vascular Surgery Cases and Innovative Techniques·Taku ToyoshimaToshiaki Mano
Apr 21, 2020·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·E Sebastian DebusUNKNOWN executive committee of the Voyager PAD trial
Mar 20, 2021·International Angiology : a Journal of the International Union of Angiology·Pavel PoredosArmando Mansilha
Jun 5, 2019·Journal of Vascular Surgery·Michael S ConteUNKNOWN GVG Writing Group
Jun 25, 2021·Angiologii︠a︡ i sosudistai︠a︡ khirurgii︠a︡ = Angiology and vascular surgery·M R KuznetsovP A Karalkin
Jul 24, 2021·Journal of the American College of Cardiology·Gregory L Moneta
May 20, 2021·Journal of the American College of Cardiology·Rupert M BauersachsUNKNOWN VOYAGER PAD Committees and Investigators
Aug 14, 2021·Journal of the American College of Cardiology·Judith HsiaMarc P Bonaca
Sep 17, 2021·Angiologii︠a︡ i sosudistai︠a︡ khirurgii︠a︡ = Angiology and vascular surgery·R A BredikhinR N Khaĭrullin
Nov 28, 2020·Current Pharmaceutical Design·Andrea DemarchiEmmanuel Androulakis

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