Rationale and design of a randomized trial to assess the safety and efficacy of MultiPoint Pacing (MPP) in cardiac resynchronization therapy: The MPP Trial

Annals of Noninvasive Electrocardiology : the Official Journal of the International Society for Holter and Noninvasive Electrocardiology, Inc
Gery TomassoniMPP Investigators

Abstract

Although the majority of Class III congestive heart failure (HF) patients treated with cardiac resynchronization therapy (CRT) show a clinical benefit, up to 40% of patients do not respond to CRT. This paper reports the design of the MultiPoint Pacing (MPP) trial, a prospective, randomized, double-blind, controlled study to evaluate the safety and efficacy of CRT using MPP compared to standard biventricular (Bi-V) pacing. A maximum of 506 patients with a standard CRT-D indication will be enrolled at up to 50 US centers. All patients will be implanted with a CRT-D system (Quartet LV lead Model 1458Q with a Quadra CRT-D, Abbott) that can deliver both MPP and Bi-V pacing. Standard Bi-V pacing will be activated at implant. At 3 months postimplant, patients in whom the echocardiographic parameters during MPP are equal or better than during Bi-V pacing are randomized (1:1) to either an MPP or Bi-V arm. The primary safety endpoint is freedom from system-related complications at 9 months. Each patient's response to CRT will be evaluated using a heart-failure clinical composite score, consisting of a change in NYHA functional class, patient global assessment score, HF events, and cardiovascular death. The primary efficacy endpoint is th...Continue Reading

References

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Mar 1, 2013·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Bernard ThibaultTaraneh G Farazi
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Feb 15, 2014·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Anoop K ShettyC Aldo Rinaldi
Mar 15, 2014·Journal of Interventional Cardiac Electrophysiology : an International Journal of Arrhythmias and Pacing·C Aldo RinaldiTasneem Z Naqvi
Sep 13, 2014·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Christopher Aldo RinaldiChristophe Leclercq
Jan 28, 2015·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Francesco ZanonFrits W Prinzen
Feb 14, 2015·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Carlo PapponeVincenzo Santinelli

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Citations

Mar 7, 2018·Current Treatment Options in Cardiovascular Medicine·Neal A Chatterjee, E Kevin Heist
Aug 6, 2017·Current Heart Failure Reports·Antonios P AntoniadisChristopher Aldo Rinaldi
Apr 19, 2018·Current Heart Failure Reports·Adam GrimaldiJohn Rickard
Oct 9, 2020·Circulation. Arrhythmia and Electrophysiology·Niraj VarmaRaffaele Corbisiero

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