Rationale and design of MultiSELECt: A European Multicenter Study on the Effect of Lipoprotein(a) Elimination by lipoprotein apheresis on Cardiovascular outcomes

Atherosclerosis. Supplements
Bernd HohensteinWolfgang Ramlow

Abstract

Dyslipidemia is a well-known risk factor for atherosclerosis and subsequent cardiovascular disease (CVD). While low density lipoprotein cholesterol (LDL-C) is well-established and taken into consideration for risk management and therapy, lipoprotein(a) is another established CVD risk factor frequently not undergoing screening due to a lack of medical treatment options. For patients suffering from CVD due to massive elevation of Lp(a) in presence of normal LDL-C levels, lipoprotein apheresis is the only available treatment option. While this constellation is an accepted indication for lipoprotein apheresis (LA) in Germany, prospective studies including a control group are still lacking. Primary objective of this trial is to evaluate the clinical benefit of lipoprotein apheresis on myocardial infarction, PCI, CABG and death from cardiovascular disease in subjects with elevated Lp(a). This study evaluates the clinical benefit of weekly LA in subjects with progressive cardiovascular disease, as accepted by the German Federal Joint Committee (treatment group). Comparator will be well-matched subjects under maximum tolerated lipid lowering therapy without access to LA treatment (control group). MultiSELECt, is a prospective, multicen...Continue Reading

Citations

Mar 16, 2019·Clinical Research in Cardiology Supplements·Norbert Weiss, Ulrich Julius
Mar 27, 2021·Journal of the American College of Cardiology·Sotirios TsimikasErik S Stroes
Jun 20, 2021·Current Atherosclerosis Reports·Anum SaeedSalim S Virani
Jul 9, 2021·Current Atherosclerosis Reports·David RhaindsJean-Claude Tardif
Dec 11, 2019·Atherosclerosis. Supplements·Ulrich JuliusStefan R Bornstein
Oct 26, 2021·Journal of Cardiovascular Pharmacology·Helen MelitaAntonis S Manolis

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