Rationale, design and baseline characteristics of the Microbiome and Insulin Longitudinal Evaluation Study (MILES).

Diabetes, Obesity & Metabolism
Elizabeth T JensenMark O Goodarzi

Abstract

To investigate the role of the gut microbiome in regulating key insulin homeostasis traits (insulin sensitivity, insulin secretion and insulin clearance) whose dysfunction leads to type 2 diabetes (T2D). The Microbiome and Insulin Longitudinal Evaluation Study (MILES) focuses on African American and non-Hispanic white participants aged 40-80 years without diabetes. Three study visits are planned (at baseline, 15 and 30 months). Baseline measurements include assessment of the stool microbiome and administration of an oral glucose tolerance test, which will yield indexes of insulin sensitivity, insulin secretion and insulin clearance. The gut microbiome profile (composition and function) will be determined using whole metagenome shotgun sequencing along with analyses of plasma short chain fatty acids. Additional data collected include dietary history, sociodemographic factors, health habits, anthropometry, medical history, medications and family history. Most assessments are repeated 15 and 30 months following baseline. After screening 875 individuals, 129 African American and 224 non-Hispanic white participants were enrolled. At baseline, African American participants have higher blood pressure, weight, body mass index, waist an...Continue Reading

References

Oct 1, 1994·Diabetic Medicine : a Journal of the British Diabetic Association·K Osei, D P Schuster
Sep 23, 1997·Scandinavian Journal of Gastroenterology·S J Lewis, K W Heaton
Sep 24, 1999·Journal of Women's Health & Gender-based Medicine·B E AinsworthL M Stolarczyk
Dec 22, 2006·Nature·Peter J TurnbaughJeffrey I Gordon
Sep 27, 2007·American Journal of Physiology. Endocrinology and Metabolism·Anna KotronenHannele Yki-Järvinen
Jul 1, 2010·Diabetes Care·Ralph A DeFronzo, Masafumi Matsuda
Jul 28, 2010·Journal of Clinical Gastroenterology·Froukje J VerdamWillem A Buurman
Aug 4, 2010·Proceedings of the National Academy of Sciences of the United States of America·Carlotta De FilippoPaolo Lionetti
Jun 3, 2011·American Journal of Physiology. Endocrinology and Metabolism·Mark O GoodarziJerome I Rotter
Aug 4, 2011·European Journal of Clinical Nutrition·J ZimmerP Enck
Jun 16, 2012·Nature·UNKNOWN Human Microbiome Project Consortium
May 31, 2013·Nature·Fredrik H KarlssonFredrik Bäckhed
Jul 6, 2013·Science·Jeremiah J FaithJeffrey I Gordon
Aug 30, 2013·Nature·Emmanuelle Le ChatelierOluf Pedersen
Dec 10, 2013·Journal of Hepatology·Anne VriezeMax Nieuwdorp
Dec 18, 2013·Nature·Lawrence A DavidPeter J Turnbaugh
Aug 12, 2015·Nature Reviews. Endocrinology·Emanuel E CanforaEllen E Blaak
Nov 18, 2015·Scientific Reports·Jocelyn M ChooGeraint B Rogers
Dec 15, 2015·Gut·Floris ImhannAlexandra Zhernakova
Jun 28, 2019·BMJ Open Diabetes Research & Care·Stephen R BenoitEdward W Gregg
Dec 6, 2019·BMJ Open Diabetes Research & Care·Zhila Semnani-AzadAnthony J Hanley
Dec 22, 2019·Diabetes Care·UNKNOWN American Diabetes Association
Mar 12, 2020·Current Nutrition Reports·Tiantian Zhu, Mark O Goodarzi

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.