Rationale for and efficacy of prolonged-interval treatment using liposome-encapsulated amikacin in experimental Mycobacterium avium infection.

Antimicrobial Agents and Chemotherapy
S LeitzkeS Ehlers

Abstract

The potential of liposome-encapsulated antibiotics for prolonging drug application intervals was investigated by using a murine model of chronic lethal Mycobacterium avium infection. Liposomal encapsulation of amikacin, but not of ciprofloxacin, resulted in high and sustained drug levels in infected tissues, exceeding the minimal inhibitory concentration for M. avium for at least 28 days. As a consequence, once-weekly and even once-monthly treatments with liposomal amikacin significantly reduced bacterial replication in infected tissues and extended the survival time of infected mice.

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Citations

Jul 18, 2002·Antimicrobial Agents and Chemotherapy·Irma A J M Bakker-WoudenbergJohan W Mouton
Oct 11, 2016·Chemical Society Reviews·N GrimaldiN Ventosa
Apr 17, 2021·Scientific Reports·Shivang K DesaiSmritilekha Bera
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Mar 15, 2015·Journal of Drug Targeting·Sanaul MustafaV Kusum Devi
Mar 27, 2020·ACS Infectious Diseases·Azucena Gonzalez Gomez, Zeinab Hosseinidoust
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Jan 4, 2022·Journal of Biomedical Nanotechnology·Bashir A SheikhManzoor A Mir

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