PMID: 2108853Apr 1, 1990Paper

Rationale for bolus t-PA therapy to improve efficacy and safety

Chest
G Agnelli

Abstract

Tissue-type plasminogen activator has high affinity for fibrin and is activated by fibrin. Because of these properties, t-PA was initially expected to cause minimal bleeding complications. This prediction has been only partially confirmed in major clinical trials in which t-PA was given in the doses necessary for effective coronary thrombolysis. The risk of bleeding in patients receiving t-PA is correlated with increased levels of fibrin degradation products and hypofibrinogenemia, consistent with a link between systemic plasminemia and hemorrhage. Limiting t-PA-associated bleeding may therefore require measures aimed at decreasing hyperplasminemia. These measures include a short infusion of a high t-PA dose. This article presents new experimental evidence that has confirmed our previous results showing that a short infusion of t-PA is an effective and safe thrombolytic treatment.

Citations

Apr 1, 1992·Cardiovascular Drugs and Therapy·M Verstraete
Jan 1, 1995·Journal of Thrombosis and Thrombolysis·J A Purvis
Feb 1, 1992·Journal of the American College of Cardiology·S Z Goldhaber
Jan 1, 1993·The Journal of Emergency Medicine·S H ThomasE J Allison
Apr 1, 1992·Chest·G Agnelli, P Parise
Jun 15, 2011·Journal of Vascular and Interventional Radiology : JVIR·Richard ChangJay N Lozier
Jul 25, 1991·The American Journal of Cardiology·B TranchesiM Verstraete
Dec 15, 1991·The American Journal of Cardiology·J A PurvisM M Khan
Dec 11, 2002·Expert Opinion on Pharmacotherapy·Anna V Mattioli
Jan 1, 1992·The Annals of Pharmacotherapy·S C FaganS Robert
Jan 10, 2020·Blood·Cecilia Becattini, Giancarlo Agnelli

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