Rationale for fixed-dose combination therapy to reach lower blood pressure goals

Southern Medical Journal
Jan Basile

Abstract

Expert committees in the United States and Europe formulated their currently recommended target blood pressures of <140/90 mm Hg or <130/80 mm Hg in persons with diabetes, chronic kidney disease, or coronary artery disease based on the totality of clinical data available at the time. However, accumulating evidence indicates that increased risk for cardiovascular and renal complications of hypertension may begin at a threshold of 115/75 mm Hg, suggesting that benefit from treatment may occur when blood pressure targets are lower than those currently recommended. Combination therapy with two or more agents having complementary mechanisms of action is the most effective method for achieving strict blood pressure goals in high-risk patients. Several clinical trials are under way to further determine the risks and benefits of lowering blood pressure beyond the currently recommended threshold.

References

Sep 8, 2000·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·G L BakrisJ Sowers
Jan 17, 2002·The New England Journal of Medicine·R S VasanD Levy
Nov 21, 2002·JAMA : the Journal of the American Medical Association·Jackson T WrightUNKNOWN African American Study of Kidney Disease and Hypertension Study Group
Dec 20, 2002·JAMA : the Journal of the American Medical Association·UNKNOWN ALLHAT Officers and Coordinators for the ALLHAT Collaborative Research Group. The Antihypertensive and Lipid-Lowering Treatm
Jan 31, 2003·The New England Journal of Medicine·Peter GaedeOluf Pedersen
Mar 8, 2003·Archives of Internal Medicine·Janice G DouglasUNKNOWN Hypertension in African Americans Working Group of the International Society on Hypertension in Blacks
Jun 24, 2003·Journal of the American Society of Nephrology : JASN·Lawrence J AppelJackson T Wright
Oct 29, 2003·Circulation·Mark J SarnakUNKNOWN American Heart Association Councils on Kidney in Cardiovascular Disease, High Blood Pressure Research, Clinical Cardiology,
Dec 6, 2003·Hypertension·Aram V ChobanianUNKNOWN National High Blood Pressure Education Program Coordinating Committee
Dec 25, 2003·Diabetes Care·Carlos Arauz-PachecoUNKNOWN American Diabetes Association
May 11, 2004·The Journal of Clinical Hypertension·Thomas G Pickering
Nov 13, 2004·JAMA : the Journal of the American Medical Association·Steven E NissenUNKNOWN CAMELOT Investigators
Nov 13, 2004·JAMA : the Journal of the American Medical Association·Carl J Pepine
Jun 9, 2005·Nephron. Clinical Practice·K Kundhal, C E Lok
Oct 12, 2005·Archives of Internal Medicine·Robin P HertzElijah Saunders
Oct 18, 2005·The Journal of Clinical Hypertension·Thomas D GilesMichael A Weber
Jan 18, 2006·The Journal of Clinical Hypertension·Keith C Ferdinand, Elijah Saunders
Jan 31, 2006·The American Journal of Medicine·Abhijit V KshirsagarRomulo E Colindres
Aug 15, 2006·Journal of the American College of Cardiology·Ilke SipahiSteven E Nissen
Oct 25, 2006·Current Cardiology Reports·David StewartElijah Saunders
Apr 11, 2007·Hypertension·Daniel W Jones, John E Hall
May 9, 2007·The Journal of Clinical Hypertension·Thomas GilesFeride Frech-Tamas
May 29, 2007·American Journal of Hypertension·Derek WeyckerGerry Oster
Jul 12, 2007·The American Journal of Cardiology·William C CushmanUNKNOWN ACCORD Study Group
Jul 7, 2007·Blood Pressure·Kenneth JamersonUNKNOWN ACCOMPLISH Investigators
Jan 10, 2008·Diabetes Care·UNKNOWN American Diabetes Association

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Citations

Aug 19, 2008·Southern Medical Journal·Kim A Connelly, Darren Yuen

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