Rationale for fixed-dose combinations in the treatment of hypertension: the cycle repeats

Drugs
Domenic A Sica

Abstract

Single-drug therapy remains the preferred way to begin treatment of hypertension, although in many patients this is unable to bring blood pressure (BP) to goal levels. Single-drug therapy, even when maximally titrated, is at best only modestly effective in normalising BP in Stage-I or II hypertension, which represents the majority of the hypertensive population. It is increasingly appreciated that the elusive goal of a 'normal' BP is achieved only if multi-drug therapy is employed. This is especially so when considered in the context of today's lower BP goals. The options for multi-drug therapy are quite simple: either fixed-dose combination therapy or drugs added sequentially one after another to then arrive at an effective multi-drug regimen. Advocates exist for both approaches. A considerable legacy, dating to the 1950's, exists for fixed-dose combination therapies. The rationale to this approach has remained constant. Fixed-dose combination therapy successfully reduces BP because two drugs, each typically working at a separate site, block different effector pathways. In addition, the second drug of such two-drug combinations may check counter-regulatory system activity triggered by the other. For example, a diuretic and bet...Continue Reading

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