Rationale for revision and proposed changes of the WHO diagnostic criteria for polycythemia vera, essential thrombocythemia and primary myelofibrosis

Blood Cancer Journal
T BarbuiA Tefferi

Abstract

The 2001/2008 World Health Organization (WHO)-based diagnostic criteria for polycythemia vera (PV), essential thrombocythemia (ET) and primary myelofibrosis (PMF) were recently revised to accomodate new information on disease-specific mutations and underscore distinguishing morphologic features. In this context, it seems to be reasonable to compare first major diagnostic criteria of the former WHO classifications for myeloproliferative neoplasm (MPN) and then to focus on details that have been discussed and will be proposed for the upcoming revision of diagnostic guidelines. In PV, a characteristic bone marrow (BM) morphology was added as one of three major diagnostic criteria, which allowed lowering of the hemoglobin/hematocrit threshold for diagnosis, which is another major criterion, to 16.5 g/dl/49% in men and 16 g/dl/48% in women. The presence of a JAK2 mutation remains the third major diagnostic criterion in PV. Subnormal serum erythropoietin level is now the only minor criterion in PV and is used to capture JAK2-unmutated cases. In ET and PMF, mutations that are considered to confirm clonality and specific diagnosis now include CALR, in addition to JAK2 and MPL. Also in the 2015 discussed revision, overtly fibrotic PMF i...Continue Reading

References

Nov 26, 1997·American Journal of Hematology·A RegevM Lahav
Nov 24, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·G Barosi
Mar 19, 2004·The New England Journal of Medicine·Andrew I Schafer
Jul 13, 2005·Mayo Clinic Proceedings·Ayalew TefferiDavid J Inwards
Jul 21, 2005·British Journal of Haematology·Mary F McMullinUNKNOWN General Haematology Task Force of the British Committee for Standards in Haematology
Feb 3, 2007·The New England Journal of Medicine·Linda M ScottAnthony R Green
Apr 15, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Peter J CampbellAnthony R Green
Mar 25, 2010·British Journal of Haematology·Claire N HarrisonUNKNOWN British Committee for Standards in Haematology
Jan 1, 2009·Current Hematologic Malignancy Reports·Juergen Thiele, Hans Michael Kvasnicka
Jun 16, 2011·American Journal of Hematology·Animesh PardananiAyalew Tefferi
Jul 13, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Tiziano BarbuiAyalew Tefferi
Sep 16, 2011·American Journal of Clinical Pathology·Suzanne M KoopmansKonnie M Hebeda

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Citations

Jan 19, 2016·Blood Cells, Molecules & Diseases·Karl HaslamStephen E Langabeer
Feb 24, 2016·Case Reports in Hematology·Stephen E LangabeerChristopher L Bacon
Oct 23, 2015·American Journal of Hematology·Ayalew Tefferi
Jan 1, 2016·American Journal of Hematology·Tiziano BarbuiAyalew Tefferi
Apr 14, 2016·Thrombosis Research·Tiziano Barbui, Anna Falanga
Feb 19, 2016·American Journal of Hematology·Yoseph C ElalaAyalew Tefferi
Jun 29, 2016·Hematology/oncology and Stem Cell Therapy·Karl HaslamStephen E Langabeer
Jul 19, 2016·The American Journal of Medicine·Benjamin E RosensteinAndres Wiernik
Jul 20, 2016·Journal of Cancer Research and Clinical Oncology·Kathleen Jentsch-UllrichFlorian H Heidel
Aug 9, 2016·Current Hematologic Malignancy Reports·Gunnar Birgegård
Oct 1, 2016·American Journal of Clinical Pathology·Lambert BusqueVikas Gupta
Dec 9, 2016·Tidsskrift for den Norske lægeforening : tidsskrift for praktisk medicin, ny række·Henry AlmedalHåkon Reikvam
Sep 12, 2016·Irish Journal of Medical Science·S E Langabeer
Mar 16, 2017·Journal of Cellular Physiology·Ciprian TomuleasaStefan O Ciurea
Feb 8, 2018·Journal of Thrombosis and Thrombolysis·Robert Diep, Ara Metjian
Jul 31, 2018·European Journal of Haematology·Antónia HatalovaHeinz Gisslinger
Jan 13, 2018·Blood Cancer Journal·Ayalew TefferiTiziano Barbui
Apr 4, 2018·Annals of Laboratory Medicine·Naery YangJungwon Huh
Oct 4, 2015·Current Hematologic Malignancy Reports·Paola GuglielmelliAlessandro Maria Vannucchi
May 3, 2016·British Journal of Haematology·Ing Soo TiongDavid M Ross
Aug 11, 2017·American Journal of Hematology·Ayalew TefferiAlessandro M Vannucchi
Jun 27, 2018·Journal of Experimental & Clinical Cancer Research : CR·Rodrigo Prieto-BermejoÁngel Hernández-Hernández
Aug 12, 2016·Blood·Rafael Valdés-MasXose S Puente
Nov 24, 2018·Blood Cancer Journal·Annalisa PacilliPaola Guglielmelli
Jul 11, 2020·Indian Journal of Hematology & Blood Transfusion : an Official Journal of Indian Society of Hematology and Blood Transfusion·Shrinidhi NathanyChethan Manohar
Nov 30, 2016·Blood Advances·Ayalew TefferiAnimesh Pardanani
Dec 20, 2018·Experimental Hematology & Oncology·Yee Yee YapKian Meng Chang
Nov 22, 2016·Blood Advances·Ayalew TefferiAlessandro M Vannucchi
May 7, 2020·Experimental and Clinical Transplantation : Official Journal of the Middle East Society for Organ Transplantation·Hasan Haci YeterUlver Derici
Oct 7, 2020·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·Francesca RoncagliaPaolo Giorgi Rossi
Nov 21, 2020·Wiener klinische Wochenschrift·Veronika Buxhofer-AuschHeinz Gisslinger
Nov 23, 2021·Journal of Cancer Research and Clinical Oncology·Carl C CrodelFlorian H Heidel

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