PMID: 8994308Nov 1, 1996Paper

Rationale for the use of dietary control in toxicity studies--B6C3F1 mouse

Toxicologic Pathology
A TurturroW T Allaben

Abstract

Significant variability in critical study parameters such as tumor incidences and survival, increasing tumor incidence and decreasing survival in common toxicity test models, and agent-induced changes in body weight (BW) and BW distribution all generate concern about the reproducibility, consistency, and equity of chronic toxicity tests used in regulation. These concerns have led to suggestions to control BW in chronic tests by the modulation of dietary intake without inducing malnutrition [dietary control (DC)] thereby minimizing tumor and survival variability both between and within studies. Evaluating the reports of the best controlled set of chronic experiments, the National Toxicology Program bioassay series, from studies initiated from 1981 to 1990, there is an increase in tumor incidence, especially liver tumors, with a consistent increase in BW. The studies are classified as to whether normal or aberrant BW growth curves occur. When the studies with normal growth curves are considered, the variance in the BW at 12 mo on test (BW12) can account for over 50% of the variance in liver tumor incidence. Additional stratification by study type, which alter tumor prevalences, as well as appreciation of housing effects [group ho...Continue Reading

References

Sep 1, 1992·Experimental Gerontology·A Turturro, R Hart
Jan 1, 1991·Annals of the New York Academy of Sciences·A Turturro, R W Hart
May 1, 1989·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·J K HasemanS L Eustis
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May 31, 1994·Annals of the New York Academy of Sciences·A TurturroR Hart

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Citations

May 11, 2004·Aging Clinical and Experimental Research·Peter H DuffyAngelo Turturro
Aug 31, 2004·Lab Animal·Nancy L Nadon
Jul 3, 1998·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·K P KeenanR Dixit
Oct 31, 2002·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Angelo TurturroRonald Hart
Dec 24, 2002·Biometrics·Jonathan L French, Joseph G Ibrahim
Mar 31, 1998·Environmental Health Perspectives·L T FrameJ E Leakey
Mar 1, 2009·Journal of Toxicologic Pathology·Robert R Maronpot
Jun 4, 2013·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Nigel P MooreJohnson Thomas
Aug 7, 2007·Physiology & Behavior·Mikael AltunBrun Ulfhake
Jan 31, 2002·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·R Eiben
Sep 9, 2006·The Journal of Toxicological Sciences·Tomoyuki MoriyamaMasaru Nishikibe
Jun 20, 2014·Free Radical Biology & Medicine·Rajindar S Sohal, Michael J Forster
Feb 25, 2009·Laboratory Animals·I H E KasanenT O Nevalainen
Aug 30, 2000·Human & Experimental Toxicology·A TurturroR W Hart
Aug 30, 2000·Human & Experimental Toxicology·A TurturroR W Hart
Oct 6, 1997·Nature·A TurturroR W Hart
Oct 22, 2002·ILAR Journal·Denise Fillman-Holliday, Margaret S Landi
Oct 2, 1998·Human & Experimental Toxicology·A TurturroR W Hart

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