PMID: 15332627Aug 31, 2004Paper

Rationalising the design of polymeric thermoresponsive biomaterials

Journal of Materials Science. Materials in Medicine
Yu RochevAlexander V Gorelov

Abstract

We investigated the cell adhesion and growth of a series of thermoresponsive copolymers of N-isopropylacrylamide (NIPA) and N-tert-butylacrylamide (NtBA) above their lower critical solubility temperatures (LCST). It was found that cell adhesion and growth on the solvent cast films improved with increasing the NtBA content in the copolymers. The improvement was dependent on cell line. The surfaces of copolymers were analysed by atomic force microscopy. The topography of polymer films was not dependent on composition. The differences in the cell attachment and growth were attributed to the variation of surface energy with composition. The surface energy of copolymers decreased with the increase in the NtBA content. We conclude that poly(N-isopropylacrylamide) (poly(NIPA)) is a relatively poor substrate for cell growth and proliferation. However, its ability to support cell growth can be significantly improved by suitable modification.

Citations

Feb 25, 2010·Journal of Fluorescence·Boguslaw SzczupakThomas J Glynn
Apr 10, 2013·Journal of Biomaterials Science. Polymer Edition·Maria E NashCarlos Elvira
May 17, 2007·Journal of the Royal Society, Interface·Martin T MoranYuri Rochev
Dec 25, 2008·Journal of Biomaterials Science. Polymer Edition·Nicholas A PeppasJames McGinty
Mar 12, 2011·International Journal of Pharmaceutics·Merlin RajamA B Mandal
Sep 13, 2013·Journal of Biomedical Materials Research. Part a·Xingliang FanYury Rochev
Jan 20, 2007·Journal of Biomedical Materials Research. Part a·Martin T MoranYuri Rochev
Aug 5, 2005·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Jana KroupováMiroslav Slouf
Jan 16, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Falko DoberenzThomas Groth
Sep 18, 2021·Langmuir : the ACS Journal of Surfaces and Colloids·Anastasia FrolovaSvetlana Kotova

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