Rationalizing autotransplant strategies for chronic myeloid leukemia

Leukemia & Lymphoma
G Q Daley

Abstract

The molecular genetic basis of chronic myeloid leukemia (CML) is well-defined, but until recently therapeutic approaches have been largely empiric. Conventional chemotherapy and interferon offer palliation, but only bone marrow transplantation provides for cure. Because the majority of CML patients are not candidates for allogeneic transplantation, autologous strategies have emerged as an alternative. Data from murine models of CML provide insights into the mechanisms by which autotransplant might be effective in the treatment of CML. Further dissection of the molecular pathways by which the BCR/ABL protein can induce leukemia offers the promise of a more targeted, rationally-designed therapy. When used for remission maintenance therapy following autologous bone marrow transplantation, specific inhibitors of BCR/ABL should provide for long term disease-free survival.

References

Sep 18, 1992·Cell·C L SawyersO N Witte
Dec 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·G Q DaleyD Baltimore
Feb 1, 1991·Molecular and Cellular Biology·L VarticovskiL C Cantley
Sep 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·M A KelliherN Rosenberg
Mar 1, 1989·Molecular and Cellular Biology·T G Lugo, O N Witte
Feb 28, 1986·Cell·Y Ben-NeriahD Baltimore
Apr 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·M L GishizkyO N Witte

❮ Previous
Next ❯

Citations

Oct 27, 2007·Seminars in Hematology·Eduardo Olavarria

❮ Previous
Next ❯

Related Concepts

Related Feeds

CNS Lymphoma

In CNS lymphoma, cancerous cells from lymph tissues or other parts of the body form tumors in the brain and/or spinal cord. Here is the latest research on this rare non-Hodgkin lymphoma.

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.