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Rationally designed families of orthogonal RNA regulators of translation

Nature Chemical Biology

May 1, 2012

Vivek K MutalikAdam Paul Arkin

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Abstract

Our ability to routinely engineer genetic networks for applications is limited by the scarcity of highly specific and non-cross-reacting (orthogonal) gene regulators with predictable behavior. Though antisense RNAs are attractive contenders for this purpose, quantitative understanding o...read more

Mentioned in this Paper

Mutant
Protein Biosynthesis
RNA
Antisense RNA Location
Antisense RNA
Insertion Mutation
DNA Insertion Elements
Escherichia coli
Genetic Engineering
Synthetic Biology
Paper Details
References
  • References42
  • Citations69
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Rationally designed families of orthogonal RNA regulators of translation

Nature Chemical Biology

May 1, 2012

Vivek K MutalikAdam Paul Arkin

PMID: 22446835

DOI: 10.1038/nchembio.919

Abstract

Our ability to routinely engineer genetic networks for applications is limited by the scarcity of highly specific and non-cross-reacting (orthogonal) gene regulators with predictable behavior. Though antisense RNAs are attractive contenders for this purpose, quantitative understanding o...read more

Mentioned in this Paper

Mutant
Protein Biosynthesis
RNA
Antisense RNA Location
Antisense RNA

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Paper Details
References
  • References42
  • Citations69
12345...

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