Rationally designed molecular beacons for bioanalytical and biomedical applications

Chemical Society Reviews
Jing ZhengWeihong Tan

Abstract

Nucleic acids hold promise as biomolecules for future applications in biomedicine and biotechnology. Their well-defined structures and compositions afford unique chemical properties and biological functions. Moreover, the specificity of hydrogen-bonded Watson-Crick interactions allows the construction of nucleic acid sequences with multiple functions. In particular, the development of nucleic acid probes as essential molecular engineering tools will make a significant contribution to advancements in biosensing, bioimaging and therapy. The molecular beacon (MB), first conceptualized by Tyagi and Kramer in 1996, is an excellent example of a double-stranded nucleic acid (dsDNA) probe. Although inactive in the absence of a target, dsDNA probes can report the presence of a specific target through hybridization or a specific recognition-triggered change in conformation. MB probes are typically fluorescently labeled oligonucleotides that range from 25 to 35 nucleotides (nt) in length, and their structure can be divided into three components: stem, loop and reporter. The intrinsic merit of MBs depends on predictable design, reproducibility of synthesis, simplicity of modification, and built-in signal transduction. Using resonance energ...Continue Reading

References

Aug 30, 1990·Nature·A D Ellington, J W Szostak
May 10, 1996·Journal of Molecular Biology·P FanD J Patel
May 1, 1997·Nature Biotechnology·R R Breaker
Feb 3, 1998·Nature Biotechnology·S TyagiF R Kramer
Mar 21, 1998·Science·L G KostrikisF R Kramer
Mar 1, 1996·Nature Biotechnology·S Tyagi, F R Kramer
Sep 4, 1998·Molecular and Cellular Probes·E OrtizP M Lizardi
Feb 17, 1999·Proceedings of the National Academy of Sciences of the United States of America·H M HortonS E Parker
Nov 4, 2000·Nature Biotechnology·S TyagiF R Kramer
Apr 3, 2001·Nature Biotechnology·B DubertretA J Libchaber
Jul 11, 2001·Analytical Biochemistry·N HamaguchiM Stanton
Jul 18, 2001·Journal of the American Chemical Society·N SvanvikM Kubista
Sep 6, 2001·Journal of the American Chemical Society·J AldanaX Peng
Apr 18, 2002·Genes & Development·Patrick J PaddisonDouglas S Conklin
May 15, 2002·Trends in Biotechnology·Natalia E Broude
May 25, 2002·Science·Stacey B GabrielDavid Altshuler
Jul 24, 2002·Nucleic Acids Research·Mats NilssonAnton K Raap
Oct 5, 2002·Nucleic Acids Research·Andrew TsourkasGang Bao
Apr 3, 2003·Journal of the American Chemical Society·Hui DuTodd D Krauss
Jun 26, 2003·Nucleic Acids Research·Michael Zuker
Jul 18, 2003·Proceedings of the National Academy of Sciences of the United States of America·Chunhai FanAlan J Heeger
Feb 15, 1961·Proceedings of the National Academy of Sciences of the United States of America·B D HALL, S SPIEGELMAN
Aug 1, 1962·Proceedings of the National Academy of Sciences of the United States of America·E T BOLTON, B J McCARTHY
Jul 18, 1963·Biochemical and Biophysical Research Communications·A P NYGAARD, B D HALL
May 11, 2004·The Journal of Organic Chemistry·Kazuhisa FujimotoMasahiko Inouye
Jun 11, 2004·Annual Review of Biochemistry·Gerald F Joyce
Jun 17, 2004·Journal of the American Chemical Society·Yi XiaoItamar Willner
Sep 2, 2004·Journal of the American Chemical Society·Chad E ImmoosMark W Grinstaff
Sep 16, 2004·Angewandte Chemie·Akira Ono, Humika Togashi
Oct 7, 2004·Angewandte Chemie·Yi ChenChengde Mao
Oct 20, 2004·Biochemistry·Birte Vester, Jesper Wengel
Oct 21, 2004·Journal of the American Chemical Society·Jens Brunner, Roland Kraemer
Mar 17, 2005·Angewandte Chemie·Lisa M WittenhagenShana O Kelley
Jun 18, 2005·Nucleic Acids Research·Zhiwen TangXiangxian Meng

❮ Previous
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Citations

Jan 7, 2016·Chemical Communications : Chem Comm·N KolevzonE Yavin
Jan 28, 2016·Chemistry : a European Journal·Tianjun ChangDihua Shangguan
Dec 4, 2015·The Analyst·Kristy S McKeatingJean-Francois Masson
Feb 16, 2016·Biochimica Et Biophysica Acta·Alessio Peracchi
Feb 18, 2016·Dalton Transactions : an International Journal of Inorganic Chemistry·Hai-Qing ZhaoT S Andy Hor
Mar 30, 2016·Biosensors & Bioelectronics·Liuting MoWeihong Tan
Aug 1, 2015·Chembiochem : a European Journal of Chemical Biology·Xiaoxiao Wang, Robert H E Hudson
Aug 28, 2015·Journal of the American Chemical Society·Marie-Virgine SalviaFabrizio Mancin
Jun 9, 2016·Sensors·Stefan SchrittwieserJoerg Schotter
Aug 19, 2016·Frontiers in Chemistry·Cibran Perez-GonzalezJ Carlos Penedo
Oct 4, 2016·Trends in Biotechnology·Tairong KuangDaniel Gallego-Perez
Jan 4, 2017·ACS Nano·Daniel JasinskiPeixuan Guo
Mar 7, 2017·ACS Applied Materials & Interfaces·Youshen WuDaocheng Wu
Mar 28, 2017·Journal of the American Chemical Society·Willem A Velema, Eric T Kool
Jul 18, 2017·Journal of the American Chemical Society·Zhan-Ming YingJian-Hui Jiang
Dec 1, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Olga A KrashenininaAlya G Venyaminova
Apr 16, 2018·Chemistry : a European Journal·Tadao TakadaKazushige Yamana
Feb 2, 2018·Advanced Materials·Yuezhou ZhangHongbo Zhang
Apr 18, 2018·Journal of Biophotonics·Ángela Ruiz-TórtolaJaime García-Rupérez
Jun 13, 2018·Angewandte Chemie·Chaoxing LiuXiang Zhou
Oct 20, 2018·RNA Biology·Songhee H KimHye Yoon Park
May 10, 2016·F1000Research·Lilith V J C MannackAndrea Rentmeister
Oct 18, 2018·Chemistry : a European Journal·Shu YangQianfan Yang

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