Rationally Designed Protein Building Blocks for Programmable Hierarchical Architectures

Frontiers in Chemistry
Wenbo ZhangChenxuan Wang

Abstract

Diverse natural/artificial proteins have been used as building blocks to construct a variety of well-ordered nanoscale structures over the past couple of decades. Sophisticated protein self-assemblies have attracted great scientific interests due to their potential applications in disease diagnosis, illness treatment, biomechanics, bio-optics and bio-electronics, etc. This review outlines recent efforts directed to the creation of structurally defined protein assemblies including one-dimensional (1D) strings/rings/tubules, two-dimensional (2D) planar sheets and three-dimensional (3D) polyhedral scaffolds. We elucidate various innovative strategies for manipulating proteins to self-assemble into desired architectures. The emergent applications of protein assemblies as versatile platforms in medicine and material science with improved performances have also been discussed.

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Citations

Apr 21, 2021·Chembiochem : a European Journal of Chemical Biology·Yuki MoriYoshiya Ikawa
Aug 10, 2021·Frontiers in Molecular Biosciences·Yun HaoLuo Zhang

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Methods Mentioned

BETA
GTPases
protein folding
X-ray
ELISA
atomic force microscopy
nuclear magnetic resonance

Software Mentioned

GRAMM
RosettaDesign
Rosetta
Dock
Amber

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