Rats Display Sexual Dimorphism in Phosphorylation of Brain Tau with Age.

Journal of Alzheimer's Disease : JAD
Jiahui NiuWen Hu

Abstract

Women have a two-fold higher risk than men to Alzheimer's disease (AD) at midlife. Larger brain tau burden was consistently shown in older women than age-matched men. The biological basis for this gender disparity remains elusive. We sought to know whether tau expression and phosphorylation physiologically differ between males and females. We used western blots and immunohistochemistry to compare the levels of total tau and phosphorylated tau in the hippocampus and entorhinal cortex (EC) between sexes in Wistar rats at 40 days, and 8 and 20 months of age. We detected no statistically significant difference in total tau, 3R-tau, and 4R-tau between sexes. However, female rats exhibited lower levels of tau unphosphorylated at the Tau-1 site at 40 days of age. At 8 months of age, females showed higher levels of tau phosphorylated at Ser190, Ser387, and Ser395 (Ser199, Ser396, and Ser404 of human tau, respectively) than males in EC. At 20 months of age, both brain regions of female rats consistently showed higher levels than males of tau phosphorylated at Ser253, Ser387, PHF-1 (Ser387/395), and Ser413 sites, which correspond to Ser262, Ser396, Ser396/404, and Ser422 of human tau, respectively. Rats of both sexes have comparable leve...Continue Reading

References

Jan 1, 1991·Acta Neuropathologica·H Braak, E Braak
Jun 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·K S KosikD J Selkoe
Jul 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·I Grundke-IqbalL I Binder
Sep 1, 1970·Journal of the Neurological Sciences·B E TomlinsonM Roth
Jun 1, 1995·Neurodegeneration : a Journal for Neurodegenerative Disorders, Neuroprotection, and Neuroregeneration·A BrunC Erikson
Jan 13, 1995·The Journal of Biological Chemistry·M Morishima-KawashimaY Ihara
Jul 1, 1997·Dementia and Geriatric Cognitive Disorders·A J Larner
May 26, 1998·Journal of Neuropathology and Experimental Neurology·B A Bahr, J S Vicente
Mar 10, 1999·Journal of Neurology, Neurosurgery, and Psychiatry·L LetenneurJ F Dartigues
Jul 27, 1999·Neuropathology and Applied Neurobiology·M Tolnay, A Probst
Jun 7, 2001·Proceedings of the National Academy of Sciences of the United States of America·A AlonsoK Iqbal
Oct 26, 2002·Science·Dennis J Selkoe
Jul 1, 2004·FEBS Letters·Alexander K MurashovLisa M Tatko
Jun 9, 2005·Archives of General Psychiatry·Lisa L BarnesDavid A Bennett
Jul 19, 2005·Annals of the New York Academy of Sciences·Margarita Alvarez-de-la-RosaFrederick Naftolin
Jan 24, 2007·The European Journal of Neuroscience·Jian-Zhi WangKhalid Iqbal
Dec 7, 2007·The European Journal of Neuroscience·Fei LiuCheng-Xin Gong
Feb 3, 2009·Journal of Neurochemistry·Yang YuCheng-Xin Gong
Feb 3, 2009·Acta Neuropathologica·Khalid IqbalInge Grundke-Iqbal
Nov 19, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jose F AbisambraChad A Dickey
Jan 11, 2011·Neurochemistry International·Ludovic MartinFaraj Terro
Jan 12, 2011·Progress in Neurobiology·J Middeldorp, E M Hol
Mar 2, 2011·NeuroImage·Martha SkupUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Jun 16, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jessica S DamoiseauxUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Jul 27, 2012·The Journal of Biological Chemistry·Siddhartha Mondragón-RodríguezJannic Boehm
Aug 24, 2012·Journal of Clinical and Experimental Neuropsychology·Karen IrvineTejinder K Kondel
Feb 28, 2013·Cell Stress & Chaperones·Evan J H LewisCatherine E Amara
Jan 15, 2014·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Geneviève ChêneSudha Seshadri
Apr 17, 2015·Molecular Neurodegeneration·Lixin SongLili Zhang
Oct 10, 2015·Alzheimer's & Dementia : Translational Research & Clinical Interventions·Katherine A LinUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Dec 4, 2015·Nature Reviews. Neuroscience·Yipeng Wang, Eckhard Mandelkow
Dec 5, 2015·Nature Reviews. Neurology·Khalid IqbalCheng-Xin Gong

❮ Previous
Next ❯

Related Concepts

Related Feeds

Alzheimer's Disease: Tau & TDP-43

Alzheimer's disease is a neurodegenerative disease. This feed focuses on the underlying role of tau proteins and TAR DNA-binding protein 43, as well as other genetic factors, in Alzheimer's disease.