PMID: 9526022Apr 29, 1998Paper

Rats with fimbria-fornix lesions are impaired in path integration: a role for the hippocampus in "sense of direction"

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Ian Q Whishaw, H Maaswinkel

Abstract

Animals can locate their present position in relation to a starting point and return to that starting point using cues generated by self-movement, a navigation strategy called dead-reckoning. Because contemporary research on spatial navigation suggests that some aspects of spatial navigation depend on the integrity of the hippocampal formation, whereas others do not, the present study examined whether dead-reckoning is hippocampally dependent. The task capitalized on the proclivity of foraging rats to carry large food pellets to a shelter for eating. Control rats and rats with fimbria-fornix (FF) lesions left a hidden burrow to search for one piece of food located somewhere on a circular table. The accuracy with which they returned to the burrow with the food was measured. In three experiments, rats received probe trials in which they (1) started from novel locations, (2) wore blindfolds to obscure visual cues, and (3) foraged under a condition in which surface cues, e.g., odors left by their outward searches, were displaced. Both sighted control and FF rats preferentially used visual cues for guidance when foraging from a familiar location. Control rats were accurate and FF rats were impaired in returning to novel starting loc...Continue Reading

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